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Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae.
Gene Name: | LIM homeobox transcription factor 1, alpha |
Family/Subfamily: | Transcription Factor |
Synonyms: | LMX1A, LIM/homeobox protein LMX1A, LIM/homeobox protein 1.1, LMX1, LMX-1.1, LMX1.1 |
Target Sequences: | NM_177398 NP_796372.1 Q8TE12 |
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