LIN28A / LIN28

lin-28 homolog A (C. elegans)

Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression By similarity. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

LIN28A / LIN28 (6)

Publications

No (6)

Tag

GST (1)

His (1)

Myc-DDK (Flag) (3)

Tat (1)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (1)

Biologically Active

Biologically active (1)

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Human LIN28A / LIN28 Protein (Recombinant His) - LS-G637

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Human LIN28A / LIN28 Protein (Recombinant GST) (Full Length) - LS-G35263

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

49.1 kDa

Price:

2 µg/$439

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Human LIN28A / LIN28 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70660

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.6 kDa

Price:

20 µg/$1,107

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Human LIN28A / LIN28 Protein (Recombinant Tat) - LS-G60

Source:

E. coli

Tag:

Tat

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

24.4 kDa

Price:

5 µg/$268; 25 µg/$349

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Human LIN28A / LIN28 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87685

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.6 kDa

Price:

20 µg/$150

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LIN28A / LIN28 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109825

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.6 kDa

Price:

100 µg/$494

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