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LILRB2 / ILT4

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2

LILRB2 / ILT4 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
Family/Subfamily: Immunoglobulin , not assigned-Immunoglobulin
Synonyms: LILRB2, CD85D, CD85d antigen, Ig-like transcript 4, LIR-2, MIR-10, MIR10, ILT-4, ILT4, LIR2
Target Sequences: NM_005874 NP_005865.3 Q8N423

Publications (1)

1
Heterogeneity in tertiary lymphoid structure B-cells correlates with patient survival in metastatic melanoma. Kevin T Lynch, Samuel J Young, Max O Meneveau, Nolan A Wages, Victor H Engelhard, Craig L Slingluff Jr, Ileana S Mauldin. Journal for immunotherapy of cancer. 2021 June;9: [Full Text Article] [PubMed:34103353] [PMC:PMC8190052] Related Antibodies: LS-B9762.

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Products
Proteins (11)
Over-Expression Lysate (4)
Recombinant (7)
LILRB2 / ILT4 (11)
No (11)
6His, C-terminus (2)
AVI-6His, C-terminus (1)
Fc, C-terminus (1)
GST (1)
His-T7 (1)
Myc-DDK (Flag) (5)
Human (9)
293T Cells (2)
E. coli (1)
HEK 293 Cells (3)
Human (2)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (4)
LILRB2 / ILT4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
64.8 kDa
20 µg/$215
LILRB2 / ILT4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
64.9 kDa
20 µg/$150
LILRB2 / ILT4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
64.8 kDa
100 µg/$710
Select
Human
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
74.5 kDa
10 µg/$294; 50 µg/$377
LILRB2 / ILT4 Protein - Recombinant Human Leukocyte Ig-Like Receptor B2/LILRB2/ILT4/CD85d (C-Avi-6His) Biotinylated
Select
Human
AVI-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
50.2 kDa
20 µg/$416; 100 µg/$910
LILRB2 / ILT4 Protein - 12.5% SDS-PAGE of human LILRB2 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
89.21 kDa
10 µg/$479; 25 µg/$670
LILRB2 / ILT4 Protein - Purified recombinant protein LILRB2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
64.8 kDa
20 µg/$1,107
LILRB2 / ILT4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
64.9 kDa
100 µg/$494
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.6 kDa
10 µg/$262; 50 µg/$361
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.57kD
10 µg/$262; 50 µg/$365; 500 µg/$1,585; 1 mg/$2,157
LILRB2 / ILT4 Protein - Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 By SDS-PAGE
Select
E. coli
His-T7
26.4 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
Viewing 1-11 of 11 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).