LIG4 / DNA Ligase IV

ligase IV, DNA, ATP-dependent

LIG4 / DNA Ligase IV is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.

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Products

Proteins (7)

Type

Over-Expression Lysate (6)

Recombinant (1)

Target

LIG4 / DNA Ligase IV (7)

Publications

No (7)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (6)

Species

Human (4)

Source

293T Cells (3)

HEK 293 Cells (3)

Wheat Germ Extract (1)

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Human LIG4 / DNA Ligase IV Protein (Recombinant GST, N-terminus) (aa802-911) - LS-G59121

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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LIG4 / DNA Ligase IV Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118058

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

103.8 kDa

Price:

100 µg/$494

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LIG4 / DNA Ligase IV Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119191

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

103.8 kDa

Price:

100 µg/$710

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Human LIG4 / DNA Ligase IV Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75544

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

103.8 kDa

Price:

20 µg/$215

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Human LIG4 / DNA Ligase IV Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75546

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

103.8 kDa

Price:

20 µg/$150

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Human LIG4 / DNA Ligase IV Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75547

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

103.8 kDa

Price:

20 µg/$215

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LIG4 / DNA Ligase IV Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102960

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

103.8 kDa

Price:

100 µg/$710

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