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LIF

leukemia inhibitory factor

Leukaemia inhibitory factor is a cytokine that induces macrophage differentiation. Neurotransmitters and neuropeptides, well known for their role in the communication between neurons, are also capable of activating monocytes and macrophages and inducing chemotaxis in immune cells. LIF signals through different receptors and transcription factors. LIF in conjunction with BMP2 acts in synergy on primary fetal neural progenitor cells to induce astrocytes.

Gene Name: leukemia inhibitory factor
Synonyms: LIF, DIA, Emfilermin, HILDA, Melanoma-derived LPL inhibitor, MLPLI, Leukemia inhibitory factor, CDF, D factor, Human interleukin in DA cells
Target Sequences: NM_002309 NP_002300.1 P15018

Publications (1)

1
Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer. Man-Tzu Wang, Nicole Fer, Jacqueline Galeas, Eric A Collisson, Sung Eun Kim, Jeremy Sharib, Frank McCormick. Nature communications. 2019 July;10:3055. [Full Text Article] [PubMed:31296870] [PMC:PMC6624260] Related Antibodies: LS-B7078.

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).