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LGMN / Legumain

legumain

LGMN / Legumain is a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.

Gene Name: legumain
Family/Subfamily: Protease , Cysteine C13
Synonyms: LGMN, AEP, LGMN1, Protease, cysteine 1, Asparaginyl endopeptidase, Cysteine protease 1, Legumain, PRSC1
Target Sequences: NM_005606 NP_005597.3 Q99538

☰ Filters
Products
Proteins (19)
Over-Expression Lysate (4)
Recombinant (15)
LGMN / Legumain (19)
No (19)
10His, N-terminus + Myc, C-terminus (2)
6His, C-terminus (4)
6His, N-terminus (5)
GST (1)
His (1)
His, N-Terminal (1)
Myc-DDK (Flag) (5)
Crab-eating macaque (2)
Human (9)
Mouse (6)
293T Cells (2)
Baculovirus (1)
E. coli (5)
HEK 293 Cells (3)
Human Cells (3)
Mammalian Cells (2)
Wheat Germ Extract (1)
Yeast (2)
Purified (10)
Low endotoxin level (5)
LGMN / Legumain Protein - Recombinant Legumain By SDS-PAGE
Select
E. coli
6His, N-terminus
51.4 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
LGMN / Legumain Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
LGMN / Legumain Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.72kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
LGMN / Legumain Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Yeast
6His, N-terminus
100 µg/$499; 20 µg/$364; 1 mg/$1,683
LGMN / Legumain Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Yeast
6His, N-terminus
100 µg/$570; 20 µg/$395; 1 mg/$1,973
LGMN / Legumain Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
49.67 kDa
100 µg/$494
LGMN / Legumain Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
49.43 kDa
100 µg/$494
LGMN / Legumain Protein - Recombinant Legumain By SDS-PAGE
Select
E. coli
His, N-Terminal
51.3 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.7kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353
LGMN / Legumain Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
49.43 kDa
20 µg/$150
LGMN / Legumain Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
49.67 kDa
20 µg/$150
LGMN / Legumain Protein - Purified recombinant protein LGMN was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
47.6 kDa
20 µg/$1,107
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
49.8 kDa
50 µg/$854
LGMN / Legumain Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His, N-terminus + Myc, C-terminus
39.7 kDa
1 mg/$1,679; 100 µg/$598; 20 µg/$405
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.7 kDa
10 µg/$344; 50 µg/$584
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.7 kDa
10 µg/$344; 50 µg/$584
LGMN / Legumain Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Baculovirus
10His, N-terminus + Myc, C-terminus
38.7 kDa
100 µg/$1,164; 20 µg/$475; 1 mg/$2,187
LGMN / Legumain Protein - 12.5% SDS-PAGE of human LGMN stained with Coomassie Blue
Select
Wheat Germ Extract
GST
73.15 kDa
2 µg/$439
Viewing 1-19 of 19 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).