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Immunohistochemistry Services

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LF / LTF / Lactoferrin

lactotransferrin

Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate.Lactotransferrin is a major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity, which depends on the extracellular cation concentration. Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. Can also prevent bacterial biofilm development in P.aeruginosa infection. Has weak antifungal activity against C.albicans. Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth. Promotes binding of species C adenoviruses to epithelial cells, promoting adenovirus infection. Can inhibit papillomavirus infections. Stimulates the TLR4 signaling pathway leading to NF-kappa-B activation and subsequent pro-inflammatory cytokine production while also interfering with the lipopolysaccharide (LPS)-stimulated TLR4 signaling. Inhibits neutrophil granulocyte migration to sites of apoptosis, when secreted by apoptotic cells. Stimulates VEGFA-mediated endothelial cell migration and proliferation. Binds heparin, chondroitin sulfate and possibly other glycosaminoglycans (GAGs). Also binds specifically to pneumococcal surface protein A (pspA), the lipid A portion of bacterial lipopolysaccharide (LPS), lysozyme and DNA.Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site.Kaliocin-1 has antimicrobial activity and is able to permeabilize different ions through liposomal membranes.Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors.The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.Isoform DeltaLf: transcription factor with antiproliferative properties and ability to induce cell cycle arrest. Binds to the DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters.

Gene Name: lactotransferrin
Synonyms: LTF, GIG12, Growth-inhibiting protein 12, HLF2, Lactotransferrin, Lactoferrin, LF, Neutrophil lactoferrin, Talalactoferrin
Target Sequences: NM_002343 NP_002334.2 P02788

Publications (2)

1
Mesenteric Adipose-derived Stromal Cells From Crohn's Disease Patients Induce Protective Effects in Colonic Epithelial Cells and Mice With Colitis. Hoffman JM, Sideri A, Ruiz JJ, Stavrakis D, Shih DQ, Turner JR, Pothoulakis C, Karagiannides I. Cellular and molecular gastroenterology and hepatology. 2018 February;6:1-16. [Full Text Article] [PubMed:29928668] [PMC:PMC6008259]
2
Beneficial Role of Neutrophils Through Function of Lactoferrin After Intracerebral Hemorrhage. Zhao X, Ting SM, Sun G, Roy-O'Reilly M, Mobley AS, Bautista Garrido J, Zheng X, Obertas L, Jung JE, Kruzel M, Aronowski J. Stroke; a journal of cerebral circulation. 2018 May;49:1241-1247. [Full Text Article] [PubMed:29636422] [PMC:PMC5915919]

Filtered by: None
Target
LF / LTF / Lactoferrin (252)
Reactivity
Human (174)
Mouse (43)
Rat (20)
Bovine (18)
Chicken (7)
Cow (8)
Dog (10)
Goat (9)
Hamster (1)
Monkey (11)
Pig (8)
Application
IHC (43)
IHC-Fr (10)
IHC-P (23)
WB (195)
Flo (10)
DB (3)
ELISA (113)
ICC (16)
ID (9)
IE (6)
IF (21)
IP (19)
Peptide-ELISA (1)
RIA (2)
Host
rabbit (138)
mouse (86)
goat (18)
bovine (4)
mouse-balb/c (1)
sheep (5)
Isotype
IgG (62)
IgG1 (37)
IgG1,k (32)
IgG2a (3)
IgG2b (2)
Clonality
monoclonal mc (86)
polyclonal pc (166)
Clone
119CT80.1.1 (4)
1A1 (3)
1A6 (1)
1B8 (1)
1C6 (2)
263-1K1 (1)
265-1K1 (2)
2B8 (4)
4C5 (2)
5F12,1,2 (1)
5F12.1.2 (1)
67D9 (1)
a-bC-lobe (2)
KT12 (1)
KT14 (1)
KT33 (1)
LF.2B8 (old LF-10) (1)
LF5-1D2 (2)
NI 25 (7)
Q100 (1)
Format
AP Conjugated (6)
APC (12)
APC Conjugated (17)
Biotin Conjugated (27)
Concentrated (5)
Cy3 Conjugated (12)
Cy7 Conjugated (12)
FITC Conjugated (29)
HRP Conjugated (28)
PE Conjugated (20)
Rhodamine Conjugated (1)
TRITC Conjugated (1)
Unconjugated (99)
Epitope
aa542-685 (18)
aa25-352 (16)
aa550-707 (10)
aa25-348 (8)
aa28-351 (8)
aa337-449 (8)
aa406-549 (8)
aa550-668 (8)
aa63-193 (8)
aa64-193 (8)
aa433-445 (1)
Publications
No (252)
Showing 1-25 of 252 results

IHC-plus™ LF / LTF / Lactoferrin Antibody (clone 1A1) LS-B2636
Mouse Monoclonal [clone 1A1] (IgG1) to Human LF / LTF / Lactoferrin
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-LTF / Lactoferrin antibody IHC of human breast, ductal with secretion. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

LF / LTF / Lactoferrin Antibody (aa28-351) LS-C295064
Rabbit Polyclonal to Dog LF / LTF / Lactoferrin
Dog, Human
WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $545.00
Western blot of recombinant LF / LTF / Lactoferrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western Blot; Sample: Canine Serum.

LF / LTF / Lactoferrin Antibody (clone a-bC-lobe) LS-C140195
Mouse Monoclonal [clone a-bC-lobe] (IgG1) to Bovine LF / LTF / Lactoferrin
Bovine
WB
Unconjugated
100µg  $575.00

IHC-plus™ LF / LTF / Lactoferrin Antibody LS-B11832
Rabbit Polyclonal to Human LF / LTF / Lactoferrin
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
200µl  $425.00
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Western blot of LTF Antibody in MDA-MB231 cell line lysates (35 ug/lane). LTF (arrow) was detected using the purified antibody.

IHC-plus™ LF / LTF / Lactoferrin Antibody (FITC) LS-B5693
Rabbit Polyclonal (IgG) to Human LF / LTF / Lactoferrin
Human
Flo, ICC, IF, IHC, IHC-P
FITC Conjugated
50µg 1mg/ml  $425.00
Anti-LTF / Lactoferrin antibody IHC of human spleen, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

LF / LTF / Lactoferrin Antibody (FITC) LS-C25062
Goat Polyclonal (IgG) to Bovine LF / LTF / Lactoferrin
Bovine
IHC
FITC Conjugated
100µl  $245.00; 500µl  $345.00

IHC-plus™ LF / LTF / Lactoferrin Antibody (clone 4C5) LS-B14841
Mouse Monoclonal [clone 4C5] (IgG1) to Human LF / LTF / Lactoferrin
Human
Flo, IF, IHC, IHC-P
Unconjugated
0.05mg  $425.00
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
LF / LTF / Lactoferrin3

IHC-plus™ LF / LTF / Lactoferrin Antibody LS-B10980
Rabbit Polyclonal (IgG) to Mouse LF / LTF / Lactoferrin
Mouse, Rat, Hamster, Human, Monkey
ICC, IHC, IHC-P, IP, WB
Unconjugated
50µl  $425.00
Anti-LF / LTF / Lactoferrin antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
WB: Mouse uterine fluid was probed with anti-Lactotransferrin (1:20,000 dilution).

LF / LTF / Lactoferrin Antibody (clone LF.2B8 (old LF-10)) LS-C41998
Mouse Monoclonal [clone LF.2B8 (old LF-10)] (IgG1) to Human LF / LTF / Lactoferrin
Human
ELISA, WB
Unconjugated
0.1mg  $325.00

LF / LTF / Lactoferrin Antibody (clone 1A1) LS-C52288
Mouse Monoclonal [clone 1A1] (IgG1) to Human LF / LTF / Lactoferrin
Human
ELISA, WB
Unconjugated
200µg 6.4mg/ml  $345.00

LF / LTF / Lactoferrin Antibody LS-C163919
Mouse Monoclonal (IgG1) to Human LF / LTF / Lactoferrin
Human
IF, IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human prostate carcinoma with LTF Monoclonal Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Immunofluorescence of LTF Monoclonal Antibody with paraffin-embedded human prostate carcinoma tissue. 0.05 mg/ml primary antibody was followed by PE-conjugated goat anti-mouse lgG (whole molecule). PE emits orange fluorescence.

LF / LTF / Lactoferrin Antibody (aa25-352) LS-C295067
Rabbit Polyclonal to Goat LF / LTF / Lactoferrin
Goat, Rat
WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $315.00; 1ml 0.5mg/ml  $575.00
Western blot of recombinant LF / LTF / Lactoferrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western Blot; Sample: Gallus Spleen lysate; Primary Ab: 1µg/ml Rabbit Anti-Caprine LTF Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody

LF / LTF / Lactoferrin Antibody (Biotin) LS-C147240
Goat Polyclonal to Human LF / LTF / Lactoferrin
Human
ELISA, ID, IHC, WB
Biotin Conjugated
1ml  $395.00

LF / LTF / Lactoferrin Antibody (clone NI 25, HRP) LS-C147261
Mouse Monoclonal [clone NI 25] (IgG1) to Human LF / LTF / Lactoferrin
Human
ELISA, IF, WB
HRP Conjugated
0.2mg  $590.00

LF / LTF / Lactoferrin Antibody (clone NI 25, Biotin) LS-C147258
Mouse Monoclonal [clone NI 25] (IgG1) to Human LF / LTF / Lactoferrin
Human
ELISA, IF, WB
Biotin Conjugated
0.2mg  $590.00

LF / LTF / Lactoferrin Antibody (HRP) LS-C25058
Rabbit Polyclonal (IgG) to Human LF / LTF / Lactoferrin
Human
ELISA, IHC, WB
HRP Conjugated
100µl  $275.00; 500µl  $345.00

LF / LTF / Lactoferrin Antibody LS-C125858
Bovine Polyclonal (IgG) to Human LF / LTF / Lactoferrin
Human
IP, WB
Unconjugated
100µg  $815.00

LF / LTF / Lactoferrin Antibody (clone 5F12,1,2) LS-C140194
Mouse Monoclonal [clone 5F12,1,2] (IgG1) to Bovine LF / LTF / Lactoferrin
Bovine
WB
Unconjugated
100µg  $575.00

LF / LTF / Lactoferrin Antibody (clone 119CT80.1.1) LS-C319174
Mouse Monoclonal [clone 119CT80.1.1] (IgG1,k) to Human LF / LTF / Lactoferrin
Human
ELISA, IF, IHC, WB
Unconjugated
200µl  $590.00

LF / LTF / Lactoferrin Antibody (clone 119CT80.1.1, AP) LS-C250302
Mouse Monoclonal [clone 119CT80.1.1] (IgG1,k) to Human LF / LTF / Lactoferrin
Human
ELISA, ICC, IF, IHC, WB
AP Conjugated
200µl  $740.00

LF / LTF / Lactoferrin Antibody (clone 119CT80.1.1, APC) LS-C250304
Mouse Monoclonal [clone 119CT80.1.1] (IgG1,k) to Human LF / LTF / Lactoferrin
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200µl  $740.00

LF / LTF / Lactoferrin Antibody (clone 119CT80.1.1, PE) LS-C250305
Mouse Monoclonal [clone 119CT80.1.1] (IgG1,k) to Human LF / LTF / Lactoferrin
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200µl  $740.00

LF / LTF / Lactoferrin Antibody LS-C662483
Rabbit Polyclonal to Human LF / LTF / Lactoferrin
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100µg  $325.00
Immunohistochemistry - Anti-Lactoferrin Picoband antibody
Immunohistochemistry - Anti-Lactoferrin Picoband antibody

LF / LTF / Lactoferrin Antibody (APC) LS-C517816
Rabbit Polyclonal (IgG) to Human LF / LTF / Lactoferrin
Human
ELISA
APC Conjugated
100µl  $650.00

LF / LTF / Lactoferrin Antibody (aa25-352) LS-C295073
Rabbit Polyclonal to Cow LF / LTF / Lactoferrin
Bovine, Cow
WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $315.00; 1ml 0.5mg/ml  $560.00
Western blot of recombinant LF / LTF / Lactoferrin.
Showing 1-25 of 252 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).