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LEO1

Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling.

Gene Name: Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Synonyms: LEO1, RDL
Target Sequences: NM_138792 NP_620147.1 Q8WVC0

☰ Filters
Antibodies (36)
Proteins (4)
Over-Expression Lysate (2)
Primary (36)
Recombinant (2)
LEO1 (40)
Human (34)
Mouse (12)
Rat (4)
Bat (6)
Chimpanzee (6)
Dog (6)
Gibbon (6)
Guinea pig (3)
Horse (6)
Monkey (6)
Orangutan (3)
Pig (3)
Rabbit (6)
IHC (6)
IHC-P (3)
WB (21)
DB (14)
ELISA (19)
IF (2)
IP (2)
Peptide-ELISA (1)
rabbit (36)
Product Group
IHCPlus (3)
IgG (24)
polyclonal pc (36)
APC Conjugated (3)
Azide-free (3)
Biotin Conjugated (5)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (3)
Unconjugated (15)
aa130-159 (7)
pSer10 (7)
pSer551 (7)
N-Terminus (4)
aa75-124 (4)
aa550-600 (3)
aa350-400 (1)
aa616-650 (1)
No (40)
GST (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
LEO1 Antibody - Anti-LEO1 antibody IHC of human colon, epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
LEO1 Rabbit anti-Human Polyclonal (aa550-600) Antibody
Human
IF, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
Select
LEO1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
LEO1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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LEO1 Rabbit anti-Human Polyclonal (aa130-159) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
LEO1 Antibody - Anti-LEO1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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LEO1 Rabbit anti-Human Polyclonal (pSer10) Antibody
Human
DB, IHC, IHC-P
Unconjugated
200 µl/$460
LEO1 Antibody - Detection of Human and Mouse LEO1 by Immunohistochemistry. Sample: FFPE section of human stomach carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti-LEO1 used at a dilution of 1:5000 (0.2and 1:1000 (1 Detection: DAB.
Select
LEO1 Rabbit anti-Human Polyclonal (aa550-600) Antibody
Mouse, Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
Select
LEO1 Rabbit anti-Human Polyclonal (aa130-159) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
LEO1 Rabbit anti-Human Polyclonal (aa130-159) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
LEO1 Rabbit anti-Human Polyclonal (aa130-159) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
LEO1 Rabbit anti-Human Polyclonal (aa130-159) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
LEO1 Rabbit anti-Human Polyclonal (aa130-159) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
LEO1 Rabbit anti-Human Polyclonal (aa130-159) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
LEO1 Antibody - Western blot of lysates from mouse cerebellum, rat cerebellum tissue lysate (from left to right), using Leo1 antibody diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20 ug per lane.
Select
LEO1 Rabbit anti-Mouse Polyclonal (aa616-650) Antibody
Mouse, Rat
Peptide-ELISA, WB
Unconjugated
400 µl/$393
Select
LEO1 Rabbit anti-Human Polyclonal (pSer10) Antibody
Human
DB, ELISA
Unconjugated
200 µl/$734
Select
LEO1 Rabbit anti-Human Polyclonal (pSer10) (Biotin) Antibody
Human
DB, ELISA
Biotin Conjugated
200 µl/$952
Select
LEO1 Rabbit anti-Human Polyclonal (pSer10) (FITC) Antibody
Human
DB, ELISA
FITC Conjugated
200 µl/$952
Select
LEO1 Rabbit anti-Human Polyclonal (pSer10) (APC) Antibody
Human
DB, ELISA
APC Conjugated
200 µl/$952
Select
LEO1 Rabbit anti-Human Polyclonal (pSer10) (PE) Antibody
Human
DB, ELISA
PE Conjugated
200 µl/$952
Select
LEO1 Rabbit anti-Human Polyclonal (pSer551) Antibody
Human
DB, ELISA
Unconjugated
200 µl/$734
Select
LEO1 Rabbit anti-Human Polyclonal (pSer551) (Biotin) Antibody
Human
DB, ELISA
Biotin Conjugated
200 µl/$952
Select
LEO1 Rabbit anti-Human Polyclonal (pSer551) (FITC) Antibody
Human
DB, ELISA
FITC Conjugated
200 µl/$952
Select
LEO1 Rabbit anti-Human Polyclonal (pSer551) (APC) Antibody
Human
DB, ELISA
APC Conjugated
200 µl/$952
Select
LEO1 Rabbit anti-Human Polyclonal (pSer551) (PE) Antibody
Human
DB, ELISA
PE Conjugated
200 µl/$952
Select
LEO1 Rabbit anti-Human Polyclonal (pSer551) (Azide-free) (HRP) Antibody
Human
DB, ELISA
HRP Conjugated, Azide-free
200 µl/$952
LEO1 Antibody - LEO1 antibody Western blot of Mouse Kidney lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
LEO1 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse
WB
Unconjugated
100 µl/$424
LEO1 Antibody - Detection of Human Leo1 by Immunohistochemistry. Sample: FFPE section of human stomach adenocarcinoma. Antibody: Affinity purified rabbit anti-Leo1 used at a dilution of 1:100. Epitope Retrieval Buffer-High pH (IHC-101J) was substituted for Epitope Retrieval Buffer-Reduced pH.
Select
LEO1 Rabbit anti-Human Polyclonal (aa550-600) Antibody
Mouse, Human
IHC
Unconjugated
1 µg/$295; 100 µl/$532
Viewing 1-25 of 40 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).