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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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LEO1

Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling.

Gene Name: Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Synonyms: LEO1, RDL
Target Sequences: NM_138792 NP_620147.1 Q8WVC0

Filtered By: None
Target
LEO1 (40)
Reactivity
Human (39)
Mouse (13)
Rat (9)
Bat (8)
Bovine (2)
Chicken (1)
Chimpanzee (6)
Dog (10)
Gibbon (6)
Guinea pig (6)
Horse (10)
Monkey (8)
Orangutan (3)
Pig (6)
Rabbit (10)
Xenopus (1)
Zebrafish (1)
Application
IHC (7)
IHC-P (5)
WB (22)
DB (16)
ELISA (23)
IF (4)
IP (3)
Peptide-ELISA (1)
Host
rabbit (40)
Isotype
IgG (28)
Clonality
polyclonal pc (40)
Format
AP Conjugated (3)
APC Conjugated (3)
Azide-free (3)
Biotin Conjugated (5)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (3)
Unconjugated (16)
Epitope
aa130-159 (8)
pSer10 (8)
pSer551 (8)
N-Terminus (4)
aa75-124 (4)
aa550-600 (3)
aa350-400 (1)
aa616-650 (1)
Publications
No (40)
Showing 1-25 of 40 results

LEO1 Antibody (aa550-600) IHC-plus™ LS-B5697
Rabbit Polyclonal (IgG) to Human LEO1
Human
IF IHC IHC-P IP WB
Unconjugated
50µl 1mg/ml  $485.00
Anti-LEO1 antibody IHC of human colon, epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-LEO1 antibody IHC of human colon, epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

LEO1 Antibody LS-C753722
Rabbit Polyclonal (IgG) to Human LEO1
Human
ELISA IF IHC WB
Unconjugated
100µg  $335.00

LEO1 Antibody (aa130-159) IHC-plus™ LS-B9008
Rabbit Polyclonal to Human LEO1
Human
IHC IHC-P WB
Unconjugated
200µl  $425.00
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Western blot of Leo1 (arrow) using rabbit polyclonal Leo1 Antibody (Human N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the Leo1 gene (Lane 2) (Origene Technologies).
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Western blot of Leo1 (arrow) using rabbit polyclonal Leo1 Antibody (Human N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the Leo1 gene (Lane 2) (Origene Technologies).

LEO1 Antibody (aa550-600) LS-C287100
Rabbit Polyclonal (IgG) to Human LEO1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Human
IF IHC IHC-P IP WB
Unconjugated
100µl 1mg/ml  $395.00
Detection of Human and Mouse LEO1 by Immunohistochemistry. Sample: FFPE section of human stomach carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti-LEO1 used at a dilution of 1:5000 (0.2and 1:1000 (1 Detection: DAB.
Detection of Human and Mouse LEO1 by Immunohistochemistry. Sample: FFPE section of human stomach carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti-LEO1 used at a dilution of 1:5000 (0.2and 1:1000 (1 Detection: DAB.

LEO1 Antibody (phospho-Ser10) IHC-plus™ LS-B4804
Rabbit Polyclonal to Human LEO1
Human
DB IHC IHC-P
Unconjugated
200µl  $425.00
Anti-LEO1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Dot blot of anti-Phospho-LEO1-pS10 Antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
Anti-LEO1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Dot blot of anti-Phospho-LEO1-pS10 Antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

LEO1 Antibody (aa550-600) LS-C286786
Rabbit Polyclonal (IgG) to Human LEO1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Human
IF IHC IHC-P
Unconjugated
100µl  $415.00
Detection of Human Leo1 by Immunohistochemistry. Sample: FFPE section of human stomach adenocarcinoma. Antibody: Affinity purified rabbit anti-Leo1 used at a dilution of 1:100. Epitope Retrieval Buffer-High pH (IHC-101J) was substituted for Epitope Retrieval Buffer-Reduced pH.
Detection of Mouse Leo1 by Immunohistochemistry. Sample: FFPE section of mouse colon carcinoma CT26. Antibody: Affinity purified rabbit anti-Leo1 used at a dilution of 1:100. Epitope Retrieval Buffer-High pH (IHC-101J) was substituted for Epitope Retrieval Buffer-Reduced pH.
Detection of Human Leo1 by Immunohistochemistry. Sample: FFPE section of human stomach adenocarcinoma. Antibody: Affinity purified rabbit anti-Leo1 used at a dilution of 1:100. Epitope Retrieval Buffer-High pH (IHC-101J) was substituted for Epitope Retrieval Buffer-Reduced pH.
Detection of Mouse Leo1 by Immunohistochemistry. Sample: FFPE section of mouse colon carcinoma CT26. Antibody: Affinity purified rabbit anti-Leo1 used at a dilution of 1:100. Epitope Retrieval Buffer-High pH (IHC-101J) was substituted for Epitope Retrieval Buffer-Reduced pH.

LEO1 Antibody LS-C406532
Rabbit Polyclonal (IgG) to Human LEO1
Rat, Human
ELISA IHC
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human thyroid cancer using LEO1 Polyclonal Antibody at dilution of 1:20.
Immunohistochemistry of Human thyroid cancer using LEO1 Polyclonal Antibody at dilution of 1:20.
Immunohistochemistry of Human thyroid cancer using LEO1 Polyclonal Antibody at dilution of 1:20.
Immunohistochemistry of Human thyroid cancer using LEO1 Polyclonal Antibody at dilution of 1:20.

LEO1 Antibody (aa130-159) LS-C327749
Rabbit Polyclonal (IgG) to Human LEO1
Human
ELISA WB
Unconjugated
200µl 0.25mg/ml  $530.00

LEO1 Antibody (aa130-159, Biotin) LS-C206688
Rabbit Polyclonal (IgG) to Human LEO1
Human
ELISA WB
Biotin Conjugated
200µl  $680.00

LEO1 Antibody (aa130-159, FITC) LS-C206689
Rabbit Polyclonal (IgG) to Human LEO1
Human
ELISA WB
FITC Conjugated
200µl  $680.00

LEO1 Antibody (aa130-159, Azide-free, HRP) LS-C209103
Rabbit Polyclonal (IgG) to Human LEO1
Human
ELISA WB
HRP Conjugated, Azide-free
200µl  $680.00

LEO1 Antibody (aa130-159, APC) LS-C206686
Rabbit Polyclonal (IgG) to Human LEO1
Human
ELISA WB
APC Conjugated
200µl  $680.00

LEO1 Antibody (aa130-159, AP) LS-C206687
Rabbit Polyclonal (IgG) to Human LEO1
Human
ELISA WB
AP Conjugated
200µl  $680.00

LEO1 Antibody (aa130-159, PE) LS-C206690
Rabbit Polyclonal (IgG) to Human LEO1
Human
ELISA WB
PE Conjugated
200µl  $680.00

LEO1 Antibody (aa616-650) LS-C356398
Rabbit Polyclonal to Mouse LEO1
Mouse, Rat
Peptide-ELISA WB
Unconjugated
400µl  $305.00
Western blot of lysates from mouse cerebellum, rat cerebellum tissue lysate (from left to right), using Leo1 antibody diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20 ug per lane.
Western blot of lysates from mouse cerebellum, rat cerebellum tissue lysate (from left to right), using Leo1 antibody diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20 ug per lane.

LEO1 Antibody (phospho-Ser10) LS-C327751
Rabbit Polyclonal (IgG) to Human LEO1
Human
DB ELISA
Unconjugated
200µl 0.25mg/ml  $530.00

LEO1 Antibody (phospho-Ser10, Azide-free, HRP) LS-C209105
Rabbit Polyclonal (IgG) to Human LEO1
Human
DB ELISA
HRP Conjugated, Azide-free
200µl  $680.00

LEO1 Antibody (phospho-Ser10, PE) LS-C206702
Rabbit Polyclonal (IgG) to Human LEO1
Human
DB ELISA
PE Conjugated
200µl  $680.00

LEO1 Antibody (phospho-Ser551) LS-C327750
Rabbit Polyclonal (IgG) to Human LEO1
Human
DB ELISA
Unconjugated
200µl 0.25mg/ml  $530.00

LEO1 Antibody (phospho-Ser551, Biotin) LS-C206693
Rabbit Polyclonal (IgG) to Human LEO1
Human
DB ELISA
Biotin Conjugated
200µl  $680.00

LEO1 Antibody (phospho-Ser551, FITC) LS-C206692
Rabbit Polyclonal (IgG) to Human LEO1
Human
DB ELISA
FITC Conjugated
200µl  $680.00

LEO1 Antibody (phospho-Ser551, Azide-free, HRP) LS-C209104
Rabbit Polyclonal (IgG) to Human LEO1
Human
DB ELISA
HRP Conjugated, Azide-free
200µl  $680.00

LEO1 Antibody (phospho-Ser551, AP) LS-C206691
Rabbit Polyclonal (IgG) to Human LEO1
Human
DB ELISA
AP Conjugated
200µl  $680.00

LEO1 Antibody (aa350-400) LS-C287099
Rabbit Polyclonal (IgG) to Human LEO1
Xenopus, Chicken, Zebrafish, Mouse, Rat, Human
IP WB
Unconjugated
100µl 1mg/ml  $395.00

LEO1 Antibody (N-Terminus) LS-C146517
Rabbit Polyclonal to Mouse LEO1
Rabbit, Mouse, Dog, Guinea pig, Rat, Horse, Bat, Human, Monkey
WB
Unconjugated
50µg  $365.00
LEO1 antibody Western blot of Mouse Kidney lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
LEO1 antibody Western blot of Mouse Kidney lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Showing 1-25 of 40 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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