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Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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LDOC1
leucine zipper, down-regulated in cancer 1
LDOC1 contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.
| Gene Name: | leucine zipper, down-regulated in cancer 1 |
| Synonyms: | LDOC1, Breast cancer, up-regulated 1, Mart7, BCUR1, Mar7, Protein LDOC1 |
| Target Sequences: | NM_012317 NP_036449.1 O95751 |
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