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LDOC1

leucine zipper, down-regulated in cancer 1

LDOC1 contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.

Gene Name: leucine zipper, down-regulated in cancer 1
Synonyms: LDOC1, Breast cancer, up-regulated 1, Mart7, BCUR1, Mar7, Protein LDOC1
Target Sequences: NM_012317 NP_036449.1 O95751

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).