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LDLRAD4 / C18orf1
low density lipoprotein receptor class A domain containing 4
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.
| Gene Name: | low density lipoprotein receptor class A domain containing 4 |
| Synonyms: | LDLRAD4, C18orf1, Clone 22 |
| Target Sequences: | NM_004338 NP_004329.1 O15165 |
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