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LDLR / LDL Receptor

low density lipoprotein receptor

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

Gene Name: low density lipoprotein receptor
Synonyms: LDLR, FHC, LDL receptor, LDLCQ2
Target Sequences: NM_000527 NP_000518.1 P01130

Publications (5)

1
Peroxisome Proliferator-activated receptor activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression. Duan Y, Chen Y, Hu W, Li X, Yang X, Zhou X, Yin Z, Kong D, Yao Z, Hajjar DP, Liu L, Liu Q, Han J. The Journal of biological chemistry. 2012 287:23667-77. (ICC, IHC, WB; Mouse, Human) [PubMed:22593575] [PMC:PMC3390641]
2
PCSK9 deficiency reduces atherosclerosis, apolipoprotein B secretion, and endothelial dysfunction. Sun H, Krauss RM, Chang JT, Teng BB,. Journal of lipid research. 2018 59:207-223. (WB; Human) [Full Text Article] [PubMed:29180444]
3
Effect of neoadjuvant chemotherapy on low-density lipoprotein (LDL) receptor and LDL receptor-related protein 1 (LRP-1) receptor in locally advanced breast cancer. Pires LA, Hegg R, Freitas FR, Tavares ER, Almeida CP, Baracat EC, Maranhão RC. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2012 45:557-64. (ICC; Mouse) [PubMed:22570085] Related Antibodies: LS-B1598.
4
Non-Native Conformational Isomers of the Catalytic Domain of PCSK9 Induce an Immune Response, Reduce Lipids and Increase LDL Receptor Levels. Jiang C, Nischal H, Sun H, Li L, Cao Y, Wei P, Chang JY, Teng BB. International journal of molecular sciences. 2018 February;19:pii: E640. (Human) [Full Text Article] [PubMed:29495280] [PMC:PMC5855862]
5
Integrated proteomics and metabolomics analysis reveals differential lipid metabolism in human umbilical vein endothelial cells under high and low shear stress. Gabriela Venturini, Pamella Araujo Malagrino, Kallyandra Padilha, Leonardo Yuji Tanaka, Francisco Rafael Laurindo, Rafael Dariolli, Valdemir Melechco Carvalho, Karina Helena Morais Cardozo, Jose Eduardo Krieger, Alexandre da Costa Pereira. American journal of physiology. Cell physiology. 2019 August;317:C326-C338. [Full Text Article] [PubMed:31067084] Related Antibodies: LS-B10039.
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Proteins (20)
Over-Expression Lysate (6)
Recombinant (14)
LDLR / LDL Receptor (20)
Bind (2)
ELISA (2)
Func (2)
SDS-PAGE (2)
No (20)
6His, C-terminus (2)
6His-AVI, C-terminus (1)
GST (1)
GST, N-terminus (1)
His (2)
His,C-terminus (2)
His-GST (1)
His-T7 (2)
His-T7, N-terminus (1)
Myc-DDK (Flag) (7)
Human (12)
Mouse (4)
Rat (1)
293T Cells (3)
E. coli (4)
HEK 293 Cells (6)
Human Cells (3)
Mammalian Cells (2)
Wheat Germ Extract (2)
Purified (4)
Low endotoxin level (7)
Biologically active (2)
Select
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The secreted recombinant mouse LDLR comprises 780 amino acids with a predicted molecular mass of 85.7 kDa. As a result of glycosylation, it migarates as approximately 120-130 kDa protein in SDS-PAGE under reducing conditions.
50 µg/$364; 500 µg/$1,452
LDLR / LDL Receptor Protein - Measure by its ability to bind with human PCSK9 in a functional ELISA. Immobilized human PCSK9 at 10 µg/ml (100 µl/well) can bind biotinylated recombinant human LDLR. The EC50 of biotinylated human LDLR is 0.61 µg/ml.
Select
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The secreted recombinant human LDLR comprises 777 amino acids with a predicted molecular mass of 86 kDa. As a result of different glycosylation, it migarates with the apparent molecular mass of 110-140 kDa in SDS-PAGE under reducing conditions corresponding to the mature and immature form.
50 µg/$364; 1 mg/$2,003
LDLR / LDL Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
95.38 kDa
100 µg/$494
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
86 kDa
50 µg/$649
LDLR / LDL Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
76.3 kDa
100 µg/$710
LDLR / LDL Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
77.3 kDa
100 µg/$710
LDLR / LDL Receptor Protein - Recombinant Low Density Lipoprotein Receptor By SDS-PAGE
Select
E. coli
His-T7
31.1 kDa
50 µg/$422; 10 µg/$278; 200 µg/$842; 100 µg/$672; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
LDLR / LDL Receptor Protein - Recombinant  Low Density Lipoprotein Receptor By SDS-PAGE
Select
E. coli
His-GST
60.1 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
LDLR / LDL Receptor Protein - Recombinant  Low Density Lipoprotein Receptor By SDS-PAGE
Select
E. coli
His-T7
32.3 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
84.78kD
10 µg/$288; 50 µg/$435; 500 µg/$1,585; 1 mg/$2,157
LDLR / LDL Receptor Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Select
293T Cells
Myc-DDK (Flag)
95.38 kDa
20 µg/$150
LDLR / LDL Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
77.3 kDa
20 µg/$215
LDLR / LDL Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
76.3 kDa
20 µg/$215
LDLR / LDL Receptor Protein - Purified recombinant protein LDLR was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
93 kDa
20 µg/$1,107
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
85.7 kDa
50 µg/$649
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
84.8 kDa
10 µg/$288; 50 µg/$428
LDLR / LDL Receptor Protein - Recombinant Low Density Lipoprotein Receptor (LDLR) by SDS-PAGE
Select
E. coli
His-T7, N-terminus
21.3kDa
10 µg/$271; 50 µg/$382; 200 µg/$762; 100 µg/$610; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
Select
Mammalian Cells
6His-AVI, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
90.1 kDa
20 µg/$466; 100 µg/$1,103
LDLR / LDL Receptor Protein - 12.5% SDS-PAGE of human LDLR stained with Coomassie Blue
Select
Wheat Germ Extract
GST
120.23 kDa
2 µg/$439
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).