LCP2 / SLP-76

lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

LCP2 / SLP-76 (8)

Publications

No (8)

Tag

6His, C-terminus (1)

GST (2)

His, N-Terminal (1)

Myc-DDK (Flag) (3)

T7, N-terminus + 6His, C-terminus (1)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (2)

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Human LCP2 / SLP-76 Protein (Recombinant GST) (Full Length) - LS-G29182

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

84.37 kDa

Price:

10 µg/$479; 25 µg/$670

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Mouse LCP2 / SLP-76 Protein (Recombinant His, N-Terminal) (aa202-463) - LS-G13476

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

32.9 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human LCP2 / SLP-76 Protein (Recombinant T7, N-terminus + 6His, C-terminus) (Met1-Pro533) - LS-G39845

Source:

E. coli

Tag:

T7, N-terminus + 6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

62.6kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353

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Human LCP2 / SLP-76 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81467

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60 kDa

Price:

20 µg/$150

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LCP2 / SLP-76 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115890

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60 kDa

Price:

100 µg/$494

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Human LCP2 / SLP-76 Protein (Recombinant GST) (Full Length) - LS-G29183

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

86.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human LCP2 / SLP-76 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68109

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60 kDa

Price:

20 µg/$1,107

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Human LCP2 / SLP-76 Protein (Recombinant 6His, C-terminus) (Met1-Pro533) - LS-G140268

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

62.6 kDa

Price:

10 µg/$344; 50 µg/$584

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