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LCP1 / L-Plastin
lymphocyte cytosolic protein 1 (L-plastin)
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.
| Gene Name: | lymphocyte cytosolic protein 1 (L-plastin) |
| Synonyms: | LCP1, CP64, L Plastin, LCP-1, LC64P, Lymphocyte cytosolic protein 1, PLS2, L-PLASTIN, Plastin 2, Plastin-2 |
| Target Sequences: | NM_002298 NP_002289.2 P13796 |
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