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LBP

lipopolysaccharide binding protein

LBP is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP).

Gene Name: lipopolysaccharide binding protein
Synonyms: LBP, BPIFD2, LPS-binding protein
Target Sequences: NM_004139 NP_004130.2 P18428

Publications (2)

1
Use of aspirin to intentionally induce gastrointestinal tract barrier dysfunction in feedlot cattle. Nathan G Briggs, Kristen M Brennan, Bethany J Funnell, Griffin T Nicholls, Jon P Schoonmaker. Journal of animal science. 2020 Sep;98:skaa264. [Full Text Article] [PubMed:32815992] [PMC:PMC7497817]
2
Histamine promotes adhesion of neutrophils by inhibition of autophagy in dairy cows with subacute ruminal acidosis. Kexin Wang, Zhenai Sun, Yunfei Li, Mingchao Liu, Juan J Loor, Qianming Jiang, Guowen Liu, Zhe Wang, Yuxiang Song, Xinwei Li. Journal of dairy science. 2022 September;105:7600-7614. [Full Text Article] [PubMed:35940921]

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Antibodies (99)
Primary (99)
LBP (99)
Human (66)
Mouse (28)
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Dog (2)
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rabbit (82)
mouse (9)
guinea pig (3)
rat (5)
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IgM,k (2)
monoclonal mc (14)
polyclonal pc (85)
1C7 (1)
4E8 (1)
6G3 (1)
M330-19 (2)
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aa27-481 (24)
aa226-438 (8)
aa226-480 (8)
aa25-481 (8)
aa36-474 (8)
aa143-192 (4)
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190-270 aa, Internal (1)
aa166-467 (1)
aa214-464 (1)
aa221-270 (1)
aa26-478 (1)
No (99)
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LBP Mouse anti-Human Monoclonal Antibody
Human
ELISA, Func, IHC, IHC-P, WB
Unconjugated
100 µg/$688
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LBP Mouse anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
100 µg/$890
LBP Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE), at a dilution of 1:100.
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LBP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
LBP Antibody - Western blot of recombinant LBP.
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LBP Rabbit anti-Mouse Polyclonal (aa25-481) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
LBP Antibody - Western blot of recombinant LBP.
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LBP Rabbit anti-Mouse Polyclonal (aa25-481) (Biotin) Antibody
Mouse, Rat, Human
WB
Biotin Conjugated
100 µl/$316; 200 µl/$361; 500 µl/$511; 1 ml/$587; 2 ml/$809; 5 ml/$1,317
LBP Antibody - LBP antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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LBP Rabbit anti-Human Polyclonal (aa143-192) (Biotin) Antibody
Human, Monkey, Gibbon
WB
Biotin Conjugated
100 µl/$469
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LBP Mouse anti-Human Monoclonal (4E8) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$423
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LBP Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$361
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LBP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$331
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LBP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$331
LBP Antibody - Western blot of recombinant LBP.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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LBP Rabbit anti-Cow Polyclonal (aa27-481) Antibody
Bovine, Cow, Human
WB
Unconjugated
100 µl/$323; 200 µl/$371; 500 µl/$531; 1 ml/$617; 2 ml/$850; 5 ml/$1,401
LBP Antibody - Western blot of recombinant LBP.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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LBP Rabbit anti-Cow Polyclonal (aa27-481) (Biotin) Antibody
Bovine, Cow, Human
WB
Biotin Conjugated
100 µl/$334; 200 µl/$387; 500 µl/$563; 1 ml/$678; 2 ml/$915; 5 ml/$1,541
LBP Antibody - Western blot of LBP antibody.
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LBP Rabbit anti-Pig Polyclonal (aa36-474) Antibody
Pig
WB
Unconjugated
100 µl/$323; 200 µl/$371; 500 µl/$531; 1 ml/$617; 2 ml/$850; 5 ml/$1,401
LBP Antibody - Anti-LBP antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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LBP Rabbit anti-Human Polyclonal (aa401-450) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
LBP Antibody - Anti-LBP antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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LBP Rabbit anti-Human Polyclonal (aa401-450) (Biotin) Antibody
Bovine, Pig, Horse, Human
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
LBP Antibody
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LBP Rabbit anti-Human Polyclonal (aa27-481) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279
LBP Antibody - Western blot of recombinant LBP.
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LBP Rabbit anti-Rat Polyclonal (aa226-480) Antibody
Rat
WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
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LBP Rat anti-Mouse Monoclonal (RR433-8) Antibody
Mouse
Flo, WB
Unconjugated
100 µg/$554
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LBP Rat anti-Mouse Monoclonal (M330-19) Antibody
Mouse
Flo, WB
Unconjugated
100 µg/$554
LBP Antibody - Immunohistochemistry image of paraffin-embedded human gastric cancer at a dilution of 1:100
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LBP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
LBP Antibody - Staining 293 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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LBP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
LBP Antibody - IHC of paraffin-embedded Gastric N+T using LBP antibody at 1:100 dilution.
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LBP Rabbit anti-Human Polyclonal (aa166-467) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
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LBP Mouse anti-Human Monoclonal Antibody
Rabbit, Goat, Dog, Sheep, Bovine, Rat, Pig, Human, Monkey
ELISA, Func, IP
Unconjugated
100 µg/$919
Select
LBP Mouse anti-Human Monoclonal Antibody
Human
ELISA, Func, IP
Unconjugated
100 µg/$919
Select
LBP Mouse anti-Human Monoclonal (aa26-478) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$705
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).