LATS2

large tumor suppressor kinase 2

Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

LATS2 (3)

Publications

No (3)

Tag

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

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Human LATS2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82782

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

120 kDa

Price:

20 µg/$215

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LATS2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101232

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

120 kDa

Price:

100 µg/$710

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Human LATS2 Protein (Recombinant His, N-Terminal) - LS-G145269

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

25.8 kDa

Price:

50 µg/$419

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