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Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
Gene Name: | LAS1-like (S. cerevisiae) |
Synonyms: | LAS1L, Las1-like, LAS1-like (S. cerevisiae), DJ475B7.2, Protein LAS1 homolog, RP3-475B7.2 |
Target Sequences: | NM_031206 NP_112483.1 Q9Y4W2 |
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