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LARP1 / La-Related Protein 1
La ribonucleoprotein domain family, member 1
RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. Associates with the mRNA 5'cap in an MTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery. Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation.
| Gene Name: | La ribonucleoprotein domain family, member 1 |
| Synonyms: | LARP1, La-related protein 1, LARP, KIAA0731 |
| Target Sequences: | T68207 Q6PKG0 Q6PKG0 |
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