LAMTOR1

late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

LAMTOR1 (3)

Publications

No (3)

Tag

6His, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Purification

Purified (1)

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Human LAMTOR1 Protein (Recombinant 6His, N-terminus) (aa1-161) - LS-G56795

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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LAMTOR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112128

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.6 kDa

Price:

100 µg/$494

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Human LAMTOR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84692

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.6 kDa

Price:

20 µg/$150

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