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LAMP2 / CD107b

lysosomal-associated membrane protein 2

Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.

Gene Name: lysosomal-associated membrane protein 2
Family/Subfamily: Cancer
Synonyms: LAMP2, CD107b, CD107b antigen, LAMPB, LGP110, LAMP-2
Target Sequences: NM_013995 NP_054701.1 P13473

Publications (3)

1
A missense change in the ATG4D gene links aberrant autophagy to a neurodegenerative vacuolar storage disease. Kyöstilä K, Syrjä P, Jagannathan V, Chandrasekar G, Jokinen TS, Seppälä EH, Becker D, Drögemüller M, Dietschi E, Drögemüller C, Lang J, Steffen F, Rohdin C, Jäderlund KH, Lappalainen AK, Hahn K, Wohlsein P, Baumgärtner W, Henke D, Oevermann A, Kere J, Lohi H, Leeb T. PLoS genetics. 2015 11:e1005169. (IHC; Canine) [Full Text Article] [PubMed:25875846] [PMC:PMC4398399]
2
Databases for technical aspects of immunohistochemistry. Furukawa S, Nagaike M, Ozaki K. Journal of toxicologic pathology. 2017 30:79-107. (IHC; Canine) [Full Text Article] [PubMed:28190929] [PMC:PMC5293696]
3
Basal Autophagy Is Altered in Lagotto Romagnolo Dogs with an ATG4D Mutation. Pernilla Syrjä, Tahira Anwar, Tarja Jokinen, Kaisa Kyöstilä, Karin Hultin Jäderlund, Francesca Cozzi, Cecilia Rohdin, Kerstin Hahn, Peter Wohlsein, Wolfgang Baumgärtner, Diana Henke, Anna Oevermann, Antti Sukura, Tosso Leeb, Hannes Lohi, Eeva-Liisa Eskelinen. Veterinary pathology. 2017 Nov;54:953-963. [Full Text Article] [PubMed:28583040]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).