LAMB2 / Laminin Beta 2

laminin, beta 2 (laminin S)

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form. The full-length nature of the spliced transcript is not known.

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Products

Proteins (10)

Type

Over-Expression Lysate (2)

Recombinant (8)

Target

LAMB2 / Laminin Beta 2 (10)

Publications

No (10)

Tag

6His, N-terminus (1)

His (1)

His, N-Terminal (1)

His-GST (1)

His-T7 (3)

Myc-DDK (Flag) (3)

Species

Human (4)

Mouse (2)

Rat (3)

Source

293T Cells (1)

E. coli (7)

HEK 293 Cells (2)

Purification

Purified (1)

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Human LAMB2 / Laminin Beta 2 Protein (Recombinant His-GST) (aa38-350) - LS-G24634

Source:

E. coli

Tag:

His-GST

Molecular Weight:

65.5 kDa

Price:

10 µg/$279; 50 µg/$430; 100 µg/$687; 200 µg/$857; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142

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Human LAMB2 / Laminin Beta 2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66161

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

192.4 kDa

Price:

20 µg/$1,107

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Human LAMB2 / Laminin Beta 2 Protein (Recombinant 6His, N-terminus) (aa1530-1798) - LS-G22625

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

33.4 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Mouse LAMB2 / Laminin Beta 2 Protein (Recombinant His, N-Terminal) (Gln1176-Asn1309) - LS-G14708

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

16.1 kDa

Price:

10 µg/$277; 50 µg/$417; 100 µg/$667; 200 µg/$832; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107

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LAMB2 / Laminin Beta 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118066

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

196 kDa

Price:

100 µg/$710

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Human LAMB2 / Laminin Beta 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77071

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

196 kDa

Price:

20 µg/$215

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Rat LAMB2 / Laminin Beta 2 Protein (Recombinant His-T7) (aa75-223) - LS-G14709

Source:

E. coli

Tag:

His-T7

Molecular Weight:

21.3 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Mouse LAMB2 / Laminin Beta 2 Protein (Recombinant His) (aa1498-1716) - LS-G14710

Source:

E. coli

Tag:

His

Molecular Weight:

25.4 kDa

Price:

10 µg/$277; 50 µg/$417; 100 µg/$667; 200 µg/$832; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107

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Rat LAMB2 / Laminin Beta 2 Protein (Recombinant His-T7) (aa1178-1311) - LS-G14713

Source:

E. coli

Tag:

His-T7

Molecular Weight:

18.4 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Rat LAMB2 / Laminin Beta 2 Protein (Recombinant His-T7) (aa939-1129) - LS-G14717

Source:

E. coli

Tag:

His-T7

Molecular Weight:

24.3 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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