L3MBTL1

L(3)mbt-like 1 (Drosophila)

Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

L3MBTL1 (4)

Publications

No (4)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human L3MBTL1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90133

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.7 kDa

Price:

20 µg/$150

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L3MBTL1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113200

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.7 kDa

Price:

100 µg/$494

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Human L3MBTL1 Protein (Recombinant GST) (Full Length) - LS-G33067

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

110.66 kDa

Price:

10 µg/$479; 25 µg/$670

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Human L3MBTL1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71581

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.7 kDa

Price:

20 µg/$1,107

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