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KRT81 / Keratin 81 / KRTHB1

keratin 81

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.

Gene Name: keratin 81
Family/Subfamily: Keratin , not assigned-Keratin
Synonyms: KRT81, GhHkb1, Hard keratin, type II, 1, HB1, Hair keratin K2.9, HB-1, Keratin, type ii hair-specific, K81, Keratin 81, Keratin, hair, basic, 1, GhHb1, MLN137, HHAKB2-1, Keratin, type II cuticular Hb1, Keratin-81, MLN 137, Type II hair keratin Hb1, Type-II keratin Kb21, KRTHB1
Target Sequences: NM_002281 NP_002272.2 Q14533

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KRT81 / Keratin 81 / KRTHB1 ELISA Kit
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).