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May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
|Gene Name:||keratin 17|
|Family/Subfamily:||Keratin , not assigned-Keratin|
|Synonyms:||KRT17, 39.1, Cytokeratin 17, Cytokeratin-17, K17, Keratin 17 epitope S2, Keratin 17 epitope S4, Keratin 17, PC2, PCHC1, CK-17, Keratin 17 epitope S1, Keratin-17|
|Target Sequences:||NM_000422 NP_000413.1 Q04695|
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