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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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KRT1 / CK1 / Cytokeratin 1

keratin 1

KRT1 / CK1 / Cytokeratin 1 is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Gene Name: keratin 1
Family/Subfamily: Keratin , not assigned-Keratin
Synonyms: KRT1, 67 kDa cytokeratin, CK-1, CK1, Cytokeratin 1, Cytokeratin-1, Epidermolytic hyperkeratosis 1, EHK, EHK1, Hair alpha protein, EPPK, NEPPK, K1, Keratin-1, KRTA, Type-II keratin Kb1, Type II keratin, Keratin 1, KRT1A
Target Sequences: NM_006121 NP_006112.3 P04264

Publications (5)

1
Activated keratinocytes in the epidermis of hypertrophic scars. Machesney M, Tidman N, Waseem A, Kirby L, Leigh I. The American journal of pathology. 1998 152:1133-41. [PubMed:9588880] [PMC:PMC1858601]
2
Characterization and comparison of reconstructed skin models: morphological and immunohistochemical evaluation. Boelsma E, Gibbs S, Faller C, Ponec M. Acta dermato-venereologica. 80:82-8. [PubMed:10877124]
3
A human keratin 10 knockout causes recessive epidermolytic hyperkeratosis. Mller FB, Huber M, Kinaciyan T, Hausser I, Schaffrath C, Krieg T, Hohl D, Korge BP, Arin MJ. Human molecular genetics. 2006 15:1133-41. (ICC) [PubMed:16505000]
4
Modified plastic compression of collagen hydrogels provides an ideal matrix for clinically applicable skin substitutes. Braziulis E, Diezi M, Biedermann T, Pontiggia L, Schmucki M, Hartmann-Fritsch F, Luginbhl J, Schiestl C, Meuli M, Reichmann E. Tissue engineering. Part C, Methods. 2012 18:464-74. (ICC, IHC; Human) [PubMed:22195768]
5
Human amniotic fluid derived cells can competently substitute dermal fibroblasts in a tissue-engineered dermo-epidermal skin analog. Hartmann-Fritsch F, Hosper N, Luginbhl J, Biedermann T, Reichmann E, Meuli M. Pediatric surgery international. 2013 29:61-9. (ICC, IHC; Human) [PubMed:23138462]
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KRT1 / CK1 / Cytokeratin 1 Antibody - Anti-Cytokeratin 1 / Keratin 1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
Rabbit Polyclonal (IgG) to Human KRT1 / CK1 / Cytokeratin 1
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   $425.00
KRT1 / CK1 / Cytokeratin 1 Antibody - Anti-KRT1 / Cytokeratin 1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human KRT1 / CK1 / Cytokeratin 1
Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
KRT1 / CK1 / Cytokeratin 1 Antibody - Anti-KRT1 / Cytokeratin 1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human KRT1 / CK1 / Cytokeratin 1
Human, Monkey, Chimpanzee, Gibbon
IHC, IHC-P, WB
HRP Conjugated
100µl   0.65mg/ml   $405.00
KRT1 / CK1 / Cytokeratin 1 Antibody - Anti-KRT1 / Cytokeratin 1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human KRT1 / CK1 / Cytokeratin 1
Human, Monkey, Chimpanzee, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100µl   1mg/ml   $405.00
KRT1 / CK1 / Cytokeratin 1 Antibody - Anti-KRT1 / Cytokeratin 1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human KRT1 / CK1 / Cytokeratin 1
Human, Monkey, Chimpanzee, Gibbon
IHC, IHC-P, WB
FITC Conjugated
100µl   1mg/ml   $405.00
KRT1 / CK1 / Cytokeratin 1 Antibody
Select
Rabbit Polyclonal (IgG) to Human KRT1 / CK1 / Cytokeratin 1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $265.00
KRT1 / CK1 / Cytokeratin 1 Antibody - Immunohistochemistry of human skin tissue using Cytokeratin 1 (human)monoclonal antibody (34 beta B4) at a dilution of 1:20.
Select
Mouse Monoclonal [clone 34BetaB4] (IgG1) to Human KRT1 / CK1 / Cytokeratin 1
Human
IHC, IHC-P, WB
Unconjugated
0.5ml   $355.00
KRT1 / CK1 / Cytokeratin 1 Antibody - IHC analysis of FFPE liver tissue, colon carcinoma, lung carcinoma, and esophagus using DAB staining
Select
Mouse Monoclonal [clone 3C10F7, 3C10G5] (IgG1) to Human KRT1 / CK1 / Cytokeratin 1
ELISA, IHC, IHC-Fr, WB
Unconjugated
100µl   1mg/ml   $315.00
KRT1 / CK1 / Cytokeratin 1 Antibody - Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Select
Rabbit Polyclonal (IgG) to Human KRT1 / CK1 / Cytokeratin 1
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human KRT1 / CK1 / Cytokeratin 1
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100µg   $355.00
Select
Mouse Monoclonal (IgG2a,k) to Human KRT1 / CK1 / Cytokeratin 1
Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µg   $530.00
KRT1 / CK1 / Cytokeratin 1 Antibody - Cytokeratin 1 antibody IHC-paraffin. IHC(P): Rat Lung Tissue.
Select
Rabbit Polyclonal to Mouse KRT1 / CK1 / Cytokeratin 1
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100µg   $355.00
KRT1 / CK1 / Cytokeratin 1 Antibody
Select
Rabbit Polyclonal (IgG) to Human KRT1 / CK1 / Cytokeratin 1
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100µg   $435.00
KRT1 / CK1 / Cytokeratin 1 Antibody - Western blot of recombinant KRT1 / CK1 / Cytokeratin 1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human KRT1 / CK1 / Cytokeratin 1
Mouse, Rat, Pig, Human
ICC, IP, WB
Unconjugated
100µl   0.5mg/ml   $245.00; 200µl   0.5mg/ml   $285.00; 500µl   0.5mg/ml   $415.00; 1ml   0.5mg/ml   $475.00
KRT1 / CK1 / Cytokeratin 1 Antibody - CK1 alpha Antibody in Immunohistochemistry (IHC)
Select
Mouse Monoclonal [clone 3C10F7, 3C10G5, PMC01, 4D12B3,3C10F7C11] (IgG1) to Human KRT1 / CK1 / Cytokeratin 1
Human
IHC, WB
Unconjugated
100µl   $425.00
KRT1 / CK1 / Cytokeratin 1 Antibody - Detection limit for recombinant GST tagged KRT1 is 0.3 ng/ml as a capture antibody.
Select
Mouse Monoclonal [clone 2A7] (IgG2a,k) to Human KRT1 / CK1 / Cytokeratin 1
Human
ELISA, WB
Unconjugated
100µg   $365.00
Select
Guinea pig Polyclonal to Human KRT1 / CK1 / Cytokeratin 1
Mouse, Human
IHC, WB
Unconjugated
100µl   $635.00
KRT1 / CK1 / Cytokeratin 1 Antibody - Western blot of recombinant KRT1 / CK1 / Cytokeratin 1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Mouse KRT1 / CK1 / Cytokeratin 1
Mouse, Rat
WB
Unconjugated
100µl   0.5mg/ml   $255.00; 200µl   0.5mg/ml   $285.00; 500µl   0.5mg/ml   $415.00; 1ml   0.5mg/ml   $485.00
KRT1 / CK1 / Cytokeratin 1 Antibody - Western blot of recombinant KRT1 / CK1 / Cytokeratin 1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Mouse KRT1 / CK1 / Cytokeratin 1
Mouse, Rat
WB
HRP Conjugated
200µl   0.5mg/ml   $325.00; 500µl   0.5mg/ml   $495.00; 1ml   0.5mg/ml   $635.00
KRT1 / CK1 / Cytokeratin 1 Antibody - Western blot of recombinant KRT1 / CK1 / Cytokeratin 1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Mouse KRT1 / CK1 / Cytokeratin 1
Mouse, Rat
WB
Biotin Conjugated
200µl   0.5mg/ml   $305.00; 500µl   0.5mg/ml   $445.00; 1ml   0.5mg/ml   $530.00
KRT1 / CK1 / Cytokeratin 1 Antibody - Western blot of recombinant KRT1 / CK1 / Cytokeratin 1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Mouse KRT1 / CK1 / Cytokeratin 1
Mouse, Rat
WB
FITC Conjugated
200µl   0.5mg/ml   $345.00; 500µl   0.5mg/ml   $545.00; 1ml   0.5mg/ml   $680.00
KRT1 / CK1 / Cytokeratin 1 Antibody - Western blot of recombinant KRT1 / CK1 / Cytokeratin 1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Mouse KRT1 / CK1 / Cytokeratin 1
Mouse, Rat
WB
APC Conjugated
200µl   0.1mg/ml   $415.00; 500µl   0.1mg/ml   $770.00; 1ml   0.1mg/ml   $965.00
KRT1 / CK1 / Cytokeratin 1 Antibody - Western blot of recombinant KRT1 / CK1 / Cytokeratin 1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Mouse KRT1 / CK1 / Cytokeratin 1
Mouse, Rat
WB
PE Conjugated
200µl   0.1mg/ml   $575.00; 500µl   0.1mg/ml   $1,155.00; 1ml   0.1mg/ml   $1,455.00
KRT1 / CK1 / Cytokeratin 1 Antibody - Western blot analysis of K2C1 expression in HEK293 cells. The lane on the left is treated with the antigen-specific peptide.
Select
Rabbit Polyclonal (IgG) to Human KRT1 / CK1 / Cytokeratin 1
Mouse, Human
ELISA, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
KRT1 / CK1 / Cytokeratin 1 Antibody - Skin 1
Select
Mouse Monoclonal [clone ABT-CK1] (IgG) to Human KRT1 / CK1 / Cytokeratin 1
Human
IHC
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).