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KREMEN1 / KREMEN-1

kringle containing transmembrane protein 1

KREMEN1 / KREMEN-1 is a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.

Gene Name: kringle containing transmembrane protein 1
Synonyms: KREMEN1, Dickkopf receptor, KREMEN, Kremen protein 1, KRM1, KREMEM1
Target Sequences: NM_001039570 NP_114434.3 Q96MU8

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).