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KREMEN1 / KREMEN-1
kringle containing transmembrane protein 1
KREMEN1 / KREMEN-1 is a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
| Gene Name: | kringle containing transmembrane protein 1 |
| Synonyms: | KREMEN1, Dickkopf receptor, KREMEN, Kremen protein 1, KRM1, KREMEM1 |
| Target Sequences: | NM_001039570 NP_114434.3 Q96MU8 |
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