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Lynnwood, WA 98036
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KMT2B / MLL4
lysine (K)-specific methyltransferase 2B
Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation.
| Gene Name: | lysine (K)-specific methyltransferase 2B |
| Synonyms: | KMT2B, Lysine N-methyltransferase 2D, MLL4, HRX2, KMT2D, WBP-7, WW domain binding protein 7, Trithorax homologue 2, WBP7, KIAA0304, Lysine N-methyltransferase 2B, Trithorax homolog 2, TRX2, WW domain-binding protein 7 |
| Target Sequences: | NM_014727 NP_055542.1 Q9UMN6 |
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