KLRK1 / CD314 / NKG2D

killer cell lectin-like receptor subfamily K, member 1

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.

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Products

Proteins (11)

Type

Recombinant (11)

Target

KLRK1 / CD314 / NKG2D (11)

Publications

No (11)

Tag

6His, N-terminus (4)

Fc, N-terminus (1)

GST (1)

His (2)

His-T7 (2)

Species

Cynomolgus (1)

Human (8)

Mouse (1)

Rat (1)

Source

Baculovirus (1)

E. coli (4)

Human (2)

Human Cells (1)

Mammalian Cells (2)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (6)

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Mouse KLRK1 / CD314 / NKG2D Protein (Recombinant 6His, N-terminus) (aa90-232) - LS-G24467

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

20.1 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Rat KLRK1 / CD314 / NKG2D Protein (Recombinant His-T7) (aa75-215) - LS-G24468

Source:

E. coli

Tag:

His-T7

Molecular Weight:

19.6 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human KLRK1 / CD314 / NKG2D Protein (Recombinant His) - LS-G2035

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human KLRK1 / CD314 / NKG2D Protein (Recombinant 6His, N-terminus) (Phe78-Val216) - LS-G40284

Source:

Human Cells

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

16.9kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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Cynomolgus KLRK1 / CD314 / NKG2D Protein (Recombinant 6His, N-terminus) - LS-G146322

Source:

Human

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

16.9 kDa

Price:

10 µg/$276; 50 µg/$405

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Human KLRK1 / CD314 / NKG2D Protein (Recombinant His-T7) (aa92-216) - LS-G24466

Source:

E. coli

Tag:

His-T7

Molecular Weight:

18.2 kDa

Price:

10 µg/$257; 50 µg/$327; 100 µg/$465; 200 µg/$582; 1 mg/$1,517; 500 µg/$1,126; 5 mg/$2,438; 2 mg/$1,685

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Human KLRK1 / CD314 / NKG2D Protein (Recombinant GST) (Full Length) - LS-G32673

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

51.7 kDa

Price:

2 µg/$439

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Human KLRK1 / CD314 / NKG2D Protein (Recombinant His) (Phe78-Val216) - LS-G97722

Source:

Baculovirus

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

18.3 kDa

Price:

100 µg/$721; 1 mg/$4,701

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Human KLRK1 / CD314 / NKG2D Protein (Recombinant 6His, N-terminus) (Phe78-Val216) - LS-G139208

Source:

Mammalian Cells

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

16.9 kDa

Price:

10 µg/$281; 50 µg/$389

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Human KLRK1 / CD314 / NKG2D Protein (Recombinant Fc, N-terminus) (Phe78-Val216) - LS-G139346

Source:

Mammalian Cells

Tag:

Fc, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

42.4 kDa

Price:

10 µg/$277; 50 µg/$389

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Human KLRK1 / CD314 / NKG2D Protein (Recombinant) (Phe78-Val216) - LS-G55769

Source:

Human

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

42.4kD

Price:

50 µg/$395; 500 µg/$1,262; 1 mg/$1,627; 10 µg/$277

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