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Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
|Gene Name:||killer cell lectin-like receptor subfamily C, member 1|
|Synonyms:||KLRC1, CD159a antigen, NK cell receptor A, Natural killer cell lectin, NKG2, NKG2-A, NKG2A, C-lectin type II protein, CD159A, Natural killer group protein 2, NKG2-B|
|Target Sequences:||NM_002259 NP_002250.1 P26715|
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