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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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KLK3 / PSA

kallikrein-related peptidase 3

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Seum levels of KLK3 (also known as PSA) are useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms.

Gene Name: kallikrein-related peptidase 3
Family/Subfamily: Protease , Serine S1
Synonyms: KLK3, APS, Gamma-seminoprotein, Kallikrein-3, Kallikrein-related peptidase 3, P-30 antigen, Prostate specific antigen, Prostate-specific antigen, PSA, Semenogelase, KLK2A1, Seminin
Target Sequences: NM_001648 NP_001639.1 P07288

Publications (1)

1
Effect of artemisinin derivatives on apoptosis and cell cycle in prostate cancer cells. Morrissey C, Gallis B, Solazzi JW, Kim BJ, Gulati R, Vakar-Lopez F, Goodlett DR, Vessella RL, Sasaki T. Anti-cancer drugs. 2010 21:423-32. (WB) [PubMed:20130467] [PMC:PMC2953769]

Filtered by: None
Target
KLK3 / PSA (328)
Reactivity
Human (319)
Mouse (19)
Rat (17)
Application
IHC (92)
IHC-Fr (13)
IHC-P (59)
WB (94)
Flo (30)
ELISA (199)
ELISPOT (4)
ICC (7)
ID (1)
IF (27)
IP (4)
IRMA (5)
LateralFlow (30)
Peptide-ELISA (2)
RIA (6)
SwELISA (2)
Host
rabbit (79)
mouse (216)
goat (24)
chicken (2)
mouse-balb/c (5)
sheep (2)
Isotype
IgG (73)
IgG1 (114)
IgG1,k (36)
IgG2a (45)
IgG2a,k (3)
IgG2b (2)
IgG2b,k (1)
IgM (2)
IgY (2)
Clonality
monoclonal mc (220)
polyclonal pc (104)
recombinant monoclonal rmc (4)
Clone
1.B.903 (1)
1A7 (1)
1A7 or 1A7G6B6 (3)
1B1 (1)
1H12 (1)
2127485 (1)
214 (1)
2B7 (1)
2H9 (1)
3E6 (1)
4127485 (1)
5127485 (1)
5A11E2 (1)
5A11E9,5A11E2 (1)
5A6 (2)
5G6 (2)
6915780 (1)
8A12 (1)
8A6 (2)
A5D5 (1)
A67-B/E3 (6)
A67-B/E3 + 1A7 (3)
ABT-PSA (1)
AT1D10 (1)
B499 (1)
BSB-7 (2)
C3F12 (1)
ER-PR8 (2)
ER-PR8 + PA05 (1)
G654.1 (1)
GF1 (1)
KLK3/1248 (3)
KLK3/2871R (2)
KLK3/801 (3)
KLK3/801 + KLK3/1248 (3)
OTI1A1 (2)
OTI1F7 (2)
OTI2A2 (2)
OTI2C9 (2)
OTI2F3 (2)
OTI2G8 (2)
OTI3A11 (2)
OTI3C8 (2)
P1 (BGN/PSA9) (1)
P4 (BGN/PSA6) (1)
PS/2 (1)
PS1 (1)
PSAK3-1 (3)
RBT-PSA (2)
SPM352 (2)
Format
AP Conjugated (24)
APC (1)
APC Conjugated (24)
Azide-free (9)
Biotin Conjugated (29)
Carrier-free (9)
Concentrated (2)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (27)
Gold Conjugated (1)
HRP Conjugated (33)
PE Conjugated (25)
Preservative Free (2)
Ready-to-Use (10)
Unconjugated (163)
Epitope
aa25-261 (17)
aa39-261 (8)
aa111-160 (4)
aa247-261 (4)
aa220-250 (3)
Internal (2)
aa26-251 (2)
50-130 aa, Internal (1)
C Terminus (1)
C-Terminus (1)
Leu106 (1)
aa194-261 (1)
aa81-130 (1)
Publications
No (328)
Publications
Showing 1-25 of 328 results

PathPlus™ KLK3 / PSA Antibody LS-B3160
Rabbit Polyclonal (IgG) to Human KLK3 / PSA
Human
ELISA, IHC, IHC-P
Unconjugated
0.1mg  $477.00
Anti-KLK3 / PSA antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

IHC-plus™ KLK3 / PSA Antibody (aa26-251, clone 5A11E2) LS-B3470
Mouse Monoclonal [clone 5A11E2] (IgG1) to Human KLK3 / PSA
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-KLK3 / PSA antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Western blot using KLK3 mouse monoclonal antibody against truncated KLK3 recombinant protein.

PathPlus™ KLK3 / PSA Antibody (clone A5D5) LS-B8459
Mouse-Balb/c Monoclonal [clone A5D5] (IgG1) to Human KLK3 / PSA
Human
ELISPOT, Flo, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1mg  $425.00
Anti-PSA antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
Immunofluorescent staining of LNCaP cells

PathPlus™ KLK3 / PSA Antibody (clone C3F12) LS-B8460
Mouse-Balb/c Monoclonal [clone C3F12] (IgG1) to Human KLK3 / PSA
Human
ELISPOT, Flo, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1mg  $425.00
Anti-PSA antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.

PathPlus™ KLK3 / PSA Antibody (clone P4 (BGN/PSA6)) LS-B4231
Mouse Monoclonal [clone P4 (BGN/PSA6)] (IgG1) to Human KLK3 / PSA
Human
ELISA, IHC, IHC-P, WB
Unconjugated
250µg 1mg/ml  $425.00
Anti-KLK3 / PSA antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

PathPlus™ KLK3 / PSA Antibody (clone 1A7) LS-B8461
Mouse-Balb/c Monoclonal [clone 1A7] (IgG1) to Human KLK3 / PSA
Human
ELISPOT, Flo, ICC, IHC, IHC-Fr, IHC-P
Unconjugated
100µg 1mg/ml  $425.00
Anti-PSA antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Immunofluorescent staining of LNCaP cells

KLK3 / PSA Antibody (HRP) LS-C316967
Rabbit Polyclonal (IgG) to Human KLK3 / PSA
Human
ELISA, WB
HRP Conjugated
50µg 0.42mg/ml  $285.00; 100µg 0.42mg/ml  $385.00

KLK3 / PSA Antibody (aa220-250) LS-C159838
Mouse Monoclonal (IgM) to Human KLK3 / PSA
Human
WB
Unconjugated
0.1ml  $325.00
HKLK3 Antibody (C234) western blot of A549 cell line lysates (35 ug/lane). The HKLK3 antibody detected the HKLK3 protein (arrow).

PathPlus™ KLK3 / PSA Antibody (clone 3E6) LS-B8463
Mouse-Balb/c Monoclonal [clone 3E6] (IgG1) to Human KLK3 / PSA
Human
ELISPOT, Flo, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1mg  $425.00
Anti-PSA antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Immunofluorescent staining of LNCaP cells 1

KLK3 / PSA Antibody LS-C331861
Rabbit Polyclonal (IgG) to Human KLK3 / PSA
Mouse, Rat, Human
IHC, WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded mouse kidney tissue.
Immunohistochemistry of paraffin-embedded human stomach tissue.

PathPlus™ KLK3 / PSA Antibody (clone 2B7) LS-B8462
Mouse-Balb/c Monoclonal [clone 2B7] (IgG1) to Human KLK3 / PSA
Human
ELISA, Flo, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1mg  $425.00
Anti-PSA antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Immunofluorescent staining of LNCaP cells

PathPlus™ KLK3 / PSA Antibody LS-B5743
Mouse Monoclonal (IgG1) to Human KLK3 / PSA
Human
ELISA, IHC, IHC-P, IRMA
Unconjugated
0.1mg  $425.00
Anti-KLK3 / PSA antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

KLK3 / PSA Antibody LS-C84699
Mouse Monoclonal (IgG2a) to Human KLK3 / PSA
Human
ELISA
Unconjugated
1mg  $275.00

IHC-plus™ KLK3 / PSA Antibody (clone AT1D10) LS-B8973
Mouse Monoclonal [clone AT1D10] (IgG1,k) to Human KLK3 / PSA
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-KLK3 / PSA antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Western Blot: The extracts of PC-3 (40 ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human KLK3 antibody (1:500-1:5000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

KLK3 / PSA Antibody (clone 214) LS-C42132
Mouse Monoclonal [clone 214] (IgG1) to Human KLK3 / PSA
Human
ELISA
Unconjugated
1mg  $590.00

KLK3 / PSA Antibody (clone A67-B/E3) LS-C358039
Mouse Monoclonal [clone A67-B/E3] (IgG1,k) to Human KLK3 / PSA
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
20µg 0.2mg/ml  $295.00; 100µg 0.2mg/ml  $465.00
Prostate Specific Antigen PSA antibody immunohistochemistry.  This image was taken for the unmodified form of this product. Other forms have not been tested.

KLK3 / PSA Antibody (clone A67-B/E3, Ready-to-Use) LS-C389430
Mouse Monoclonal [clone A67-B/E3] (IgG1,k) to Human KLK3 / PSA
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Ready-to-Use
7ml  $465.00
Prostate Specific Antigen PSA antibody immunohistochemistry.  This image was taken for the unmodified form of this product. Other forms have not been tested.

KLK3 / PSA Antibody (clone A67-B/E3, Azide-free) LS-C389515
Mouse Monoclonal [clone A67-B/E3] (IgG1,k) to Human KLK3 / PSA
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Azide-free
100µg 1mg/ml  $465.00
Prostate Specific Antigen PSA antibody immunohistochemistry.  This image was taken for the unmodified form of this product. Other forms have not been tested.

KLK3 / PSA Antibody (50-130 aa, Internal) LS-C385673
Rabbit Polyclonal (IgG) to Human KLK3 / PSA
Human
ELISA, IF, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00

KLK3 / PSA Antibody LS-C315774
Goat Polyclonal to Human KLK3 / PSA
Human
ELISA, Flo, ID, IHC, IP, WB
Unconjugated
1mg  $315.00

KLK3 / PSA Antibody (clone P1 (BGN/PSA9)) LS-C42136
Mouse Monoclonal [clone P1 (BGN/PSA9)] (IgG1) to Human KLK3 / PSA
Human
ELISA, WB
Unconjugated
1mg  $590.00

KLK3 / PSA Antibody (clone A67-B/E3, Biotin) LS-C46297
Mouse Monoclonal [clone A67-B/E3] (IgG1) to Human KLK3 / PSA
Human
ELISA, IHC-P, WB
Biotin Conjugated
0.1mg 1mg/ml  $280.00

KLK3 / PSA Antibody LS-C84701
Mouse Monoclonal (IgG1) to Human KLK3 / PSA
Human
ELISA, IRMA
Unconjugated
1000µg 5.35mg/ml  $465.00

KLK3 / PSA Antibody LS-C84695
Mouse Monoclonal (IgG1) to Human KLK3 / PSA
Human
ELISA
Unconjugated
1mg  $385.00

KLK3 / PSA Antibody (Internal) LS-C351862
Rabbit Polyclonal to Human KLK3 / PSA
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $245.00
Immunohistochemical analysis of Kallikrein 3 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of Kallikrein 3 staining in LNCaP cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Showing 1-25 of 328 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).