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Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation By similarity. Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.
Gene Name: | kelch-like family member 2 |
Synonyms: | KLHL2, Actin-binding protein Mayven, ABP-KELCH, MAYVEN, Kelch, Kelch-like protein 2, MAV |
Target Sequences: | NM_007246 |
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