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KLF7 is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants.
Gene Name: | Kruppel-like factor 7 (ubiquitous) |
Synonyms: | KLF7, Krueppel-like factor 7, UKLF |
Target Sequences: | NM_003709 NP_003700.1 O75840 |
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