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KLF4

Kruppel-like factor 4 (gut)

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

Gene Name: Kruppel-like factor 4 (gut)
Synonyms: KLF4, EZF, GKLF, Kruppel-like factor 4 (gut), Hezf, Krueppel-like factor 4
Target Sequences: NM_004235 NP_004226.3 O43474

Publications (2)

1
Caveolin-3 Promotes a Vascular Smooth Muscle Contractile Phenotype. Gutierrez-Pajares JL, Iturrieta J, Dulam V, Wang Y, Pavlides S, Malacari G, Lisanti MP, Frank PG. Frontiers in cardiovascular medicine. 2015 2:27. (WB; Human) [Full Text Article] [PubMed:26664898] [PMC:PMC4671348] Related Antibodies: LS-B5641.
2
Immunohistochemical analysis of monocytic leukemias: usefulness of CD14 and Kruppel-like factor 4, a novel monocyte marker. Klco JM, Kulkarni S, Kreisel FH, Nguyen TD, Hassan A, Frater JL. American journal of clinical pathology. 2011 135:720-30. (IHC; Human) [Full Text Article] [PubMed:21502426] Related Antibodies: LS-B1192.

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Products
Proteins (12)
Over-Expression Lysate (4)
Recombinant (8)
KLF4 (12)
No (12)
GST (1)
GST, N-terminus (1)
His (2)
His, N-Terminal (1)
His-T7 (1)
Myc-DDK (Flag) (5)
Tat (1)
Human (9)
Mouse (1)
293T Cells (2)
E. coli (4)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Purified (4)
Low endotoxin level (1)
KLF4 Protein
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E. coli
His
50 µg/$411; 250 µg/$985; 10 µg/$276
KLF4 Protein - Recombinant Kruppel Like Factor 4, Gut By SDS-PAGE
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E. coli
His, N-Terminal
30.4 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
KLF4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
50.9 kDa
100 µg/$494
KLF4 Protein - 12.5% SDS-PAGE of human KLF4 stained with Coomassie Blue
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Wheat Germ Extract
GST
76.5 kDa
10 µg/$479; 25 µg/$670
KLF4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
49.9 kDa
20 µg/$150
KLF4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
50.9 kDa
20 µg/$150
KLF4 Protein - Purified recombinant protein KLF4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
49.9 kDa
20 µg/$1,107
KLF4 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
KLF4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
49.9 kDa
100 µg/$494
KLF4 Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Select
HEK 293 Cells
Tat
Less than 0.1 ng/µg of protein (less than 1EU/µg).
51.7 kDa
5 µg/$268; 25 µg/$349
KLF4 Protein - Recombinant Kruppel Like Factor 4, Gut By SDS-PAGE
Select
E. coli
His-T7
35.3 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).