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KLB / Beta Klotho

klotho beta

Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21.

Gene Name: klotho beta
Synonyms: KLB, BetaKlotho, Beta-klotho, BKL, Klotho beta, Klotho beta like, Klotho beta-like protein
Target Sequences: AA010359 Q86Z14 Q86Z14

Publications (8)

1
Ileal Transposition Surgery Decreases Fat Mass and Improves Glucose Metabolism in Diabetic GK Rats: Possible Involvement of FGF21. Yan K, Chen W, Zhu H, Lin G, Pan H, Li N, Wang L, Yang H, Liu M, Gong F. Frontiers in physiology. 2018 March;9:191. (Human) [Full Text Article] [PubMed:29593555] [PMC:PMC5854974] Related Antibodies: LS-B3568.
2
Hypocaloric Diet Prevents the Decrease in FGF21 Elicited by High Phosphorus Intake. Pineda C, Rios R, Raya AI, Rodriguez M, Aguilera-Tejero E, Lopez I. Nutrients. 2018 October;10:pii E1496. [Full Text Article] [PubMed:30322116] [PMC:PMC6213303] Related Antibodies: LS-B3568.
3
Mistranslation Drives Alterations in Protein Levels and the Effects of a Synonymous Variant at the Fibroblast Growth Factor 21 Locus. Ali Bayoumi, Asmaa Elsayed, Shuanglin Han, Salvatore Petta, Leon A Adams, Rocio Aller, Anis Khan, Carmelo García-Monzón, María Teresa Arias-Loste, Luca Miele, Olivier Latchoumanin, Shafi Alenizi, Rocio Gallego-Durán, Janett Fischer, Thomas Berg, Antonio Craxì, Mayada Metwally, Liang Qiao, Christopher Liddle, Hannele Yki-Järvinen, Elisabetta Bugianesi, Manuel Romero-Gomez, Jacob George, Mohammed Eslam. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2021 June;8:2004168. [Full Text Article] [PubMed:34141520] [PMC:PMC8188187]
4
The KLB rs17618244 gene variant is associated with fibrosing MAFLD by promoting hepatic stellate cell activation. Nadia Panera, Marica Meroni, Miriam Longo, Annalisa Crudele, Luca Valenti, Emanuele Bellacchio, Luca Miele, Valentina D'Oria, Erika Paolini, Marco Maggioni, Anna Ludovica Fracanzani, Anna Alisi, Paola Dongiovanni. EBioMedicine. 2021 February;65:103249. [Full Text Article] [PubMed:33640795] [PMC:PMC7921469]
5
ß-Klotho gene variation is associated with liver damage in children with NAFLD. Paola Dongiovanni, Annalisa Crudele, Nadia Panera, Ilaria Romito, Marica Meroni, Cristiano De Stefanis, Alessia Palma, Donatella Comparcola, Anna Ludovica Fracanzani, Luca Miele, Luca Valenti, Valerio Nobili, Anna Alisi. Journal of hepatology. 2020 March;72:411-419. [Full Text Article] [PubMed:31655133]
6
Screen for small molecules increasing the mitochondrial membrane potential. Montague CR, Fitzmaurice A, Hover BM, Salazar NA, Fey JP. Journal of biomolecular screening. 2014 Mar;19:387-98. [Full Text Article] [PubMed:23867716] Related Antibodies: LS-B3568.
7
MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function. Fu T, Seok S, Choi S, Huang Z, Suino-Powell K, Xu HE, Kemper B, Kemper JK. Molecular and cellular biology. Nov;34:4130-42. [Full Text Article] [PubMed:25182532] [PMC:PMC4248715] Related Antibodies: LS-B3568.
8
Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor beta -Klotho. Fu T, Choi SE, Kim DH, Seok S, Suino-Powell KM, Xu HE, Kemper JK. Proceedings of the National Academy of Sciences of the United States of America. Oct;109:16137-42. [Full Text Article] [PubMed:22988100] [PMC:PMC3479576] Related Antibodies: LS-B3568.
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Proteins (4)
Recombinant (4)
KLB / Beta Klotho (4)
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His (2)
His, N-Terminal (2)
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Mouse (3)
E. coli (4)
KLB / Beta Klotho Protein - Recombinant Klotho Beta By SDS-PAGE
Select
Human KLB / Beta Klotho Protein (Recombinant His, N-Terminal) (aa517-636) - LS-G15919
E. coli
His, N-Terminal
15.1 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
KLB / Beta Klotho Protein - Recombinant Klotho Beta (KLb) by SDS-PAGE
Select
Mouse KLB / Beta Klotho Protein (Recombinant His, N-Terminal) (Met515-Leu965) - LS-G133041
E. coli
His, N-Terminal
53.9kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,838
KLB / Beta Klotho Protein - Recombinant Klotho Beta By SDS-PAGE
Select
Mouse KLB / Beta Klotho Protein (Recombinant His) (aa380-506) - LS-G15921
E. coli
His
16.6 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
KLB / Beta Klotho Protein - Recombinant Klotho Beta By SDS-PAGE
Select
Mouse KLB / Beta Klotho Protein (Recombinant His) (aa846-965) - LS-G15922
E. coli
His
15.7 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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