KISS1 / Kisspeptin / Metastin

KiSS-1 metastasis-suppressor

Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca2+ levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.

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Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

KISS1 / Kisspeptin / Metastin (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

His-GST (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

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Mouse KISS1 / Kisspeptin / Metastin Protein (Recombinant His-GST) (aa1-126) - LS-G24945

Source:

E. coli

Tag:

His-GST

Molecular Weight:

46.1 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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Human KISS1 / Kisspeptin / Metastin Protein (Recombinant His, N-Terminal) (Glu20-Gly138) - LS-G133137

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

16.2kDa

Price:

10 µg/$259; 50 µg/$331; 200 µg/$602; 100 µg/$482; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723

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Human KISS1 / Kisspeptin / Metastin Protein (Recombinant GST, N-terminus) (aa46-145) - LS-G59069

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human KISS1 / Kisspeptin / Metastin Protein (Recombinant GST) (Full Length) - LS-G29127

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

40.81 kDa

Price:

2 µg/$439

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Human KISS1 / Kisspeptin / Metastin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68164

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

14.5 kDa

Price:

20 µg/$1,107

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Human KISS1 / Kisspeptin / Metastin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81582

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

14.5 kDa

Price:

20 µg/$150

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KISS1 / Kisspeptin / Metastin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99703

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

14.5 kDa

Price:

100 µg/$494

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Human KISS1 / Kisspeptin / Metastin Protein (Recombinant) - LS-G3487

Source:

E. coli

Tag:

None

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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