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Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis.
Gene Name: | kinesin family member 13A |
Synonyms: | KIF13A, BA500C11.2, Kinesin-like protein RBKIN, RBKIN, Kinesin family member 13A, Kinesin-like protein KIF13A |
Target Sequences: | NM_022113 NP_071396.4 Q9H1H9 |
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