KIAA0191 / ZCCHC11

zinc finger, CCHC domain containing 11

Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation.

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Proteins (1)

Type

Recombinant (1)

Target

KIAA0191 / ZCCHC11 (1)

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GST (1)

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Human (1)

Source

Wheat Germ Extract (1)

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Purified (1)

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Human KIAA0191 / ZCCHC11 Protein (Recombinant GST) (Full Length) - LS-G32800

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

60.5 kDa

Price:

10 µg/$479; 25 µg/$670

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