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KHSRP / FBP2
KH-type splicing regulatory protein
Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
| Gene Name: | KH-type splicing regulatory protein |
| Synonyms: | KHSRP, FUSE binding protein 2, KSRP, p75, FUBP2, FUSE-binding protein 2 |
| Target Sequences: | NM_003685 NP_003676.2 Q92945 |
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