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KEAP1
kelch-like ECH-associated protein 1
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
| Gene Name: | kelch-like ECH-associated protein 1 |
| Synonyms: | KEAP1, Cytosolic inhibitor of Nrf2, INrf2, KLHL19, Kelch-like protein 19, KIAA0132 |
| Target Sequences: | NM_012289 NP_036421.2 Q14145 |
Publications (1)
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