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KEAP1

kelch-like ECH-associated protein 1

Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

Gene Name: kelch-like ECH-associated protein 1
Synonyms: KEAP1, Cytosolic inhibitor of Nrf2, INrf2, KLHL19, Kelch-like protein 19, KIAA0132
Target Sequences: NM_012289 NP_036421.2 Q14145

Publications (1)

1
ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer. Vinee Purohit , Lidong Wang , Huibin Yang, Jiufeng Li, Gina M Ney, Erica R Gumkowski, Akash J Vaidya, Annie Wang, Amit Bhardwaj, Ende Zhao, Igor Dolgalev, Andrea Zamperone, Ethan V Abel, Marina Pasca Di Magliano, Howard C Crawford, Daniel Diolaiti, Thales Y Papagiannakopoulos, Costas A Lyssiotis, Diane M Simeone. Genes & development. 2021 February;35:218-233. [Full Text Article] [PubMed:33446568] [PMC:PMC7849366]

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KEAP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$923
KEAP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
23.438 - 1500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
KEAP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
KEAP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$902
KEAP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
KEAP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
KEAP1 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
1 Plate/$783
KEAP1 ELISA Kit
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Custom
96-Well Strip Plate
Pig
1 Plate/$783
KEAP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).