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KEAP1
kelch-like ECH-associated protein 1
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
| Gene Name: | kelch-like ECH-associated protein 1 |
| Synonyms: | KEAP1, Cytosolic inhibitor of Nrf2, INrf2, KLHL19, Kelch-like protein 19, KIAA0132 |
| Target Sequences: | NM_012289 NP_036421.2 Q14145 |
Publications (1)
1
ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer. Vinee Purohit , Lidong Wang , Huibin Yang, Jiufeng Li, Gina M Ney, Erica R Gumkowski, Akash J Vaidya, Annie Wang, Amit Bhardwaj, Ende Zhao, Igor Dolgalev, Andrea Zamperone, Ethan V Abel, Marina Pasca Di Magliano, Howard C Crawford, Daniel Diolaiti, Thales Y Papagiannakopoulos, Costas A Lyssiotis, Diane M Simeone. Genes & development. 2021 February;35:218-233. [Full Text Article]
[PubMed:33446568]
[PMC:PMC7849366]
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KEAP1 Goat anti-Human Polyclonal (aa41-53) Antibody
Dog, Bovine, Pig, Horse, Bat, Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
KEAP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
KEAP1 Mouse anti-Human Monoclonal (OTI1B4) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$458
KEAP1 Mouse anti-Human Monoclonal (Carrier-free) (OTI1B4) Antibody
Mouse, Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
KEAP1 Rabbit anti-Human Polyclonal (aa543-592) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
KEAP1 Rabbit anti-Human Polyclonal (aa543-592) (HRP) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Horse, Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$442
KEAP1 Rabbit anti-Human Polyclonal (aa21-70) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$923
Yeast
6His, N-terminus
500 µg/$1,052; 100 µg/$446; 20 µg/$336
Sandwich
96-Well Strip Plate
Human
23.438 - 1500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
KEAP1 Mouse anti-Human Monoclonal (1F10B6) Antibody
Human
ELISA, Flo, IF, WB
Unconjugated
100 µl/$447
KEAP1 Mouse anti-Human Monoclonal (7G4B10) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
0.1 mg/$447
E. coli
6His, N-terminus
36.5 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$3,361
Sandwich
96-Well Strip Plate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
HEK 293 Cells
Myc-DDK (Flag)
69.5 kDa
20 µg/$1,107
Baculovirus
His-GST-AVI, N-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human KEAP1/GST chimera consists of 875 amino acids and has a calculated molecular mass of 99.2 kDa. It migrates as an approximately 85 kDa band in SDS-PAGE under reducing conditions.
100 µg/$441
KEAP1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
KEAP1 Rabbit anti-Human Polyclonal (aa422-449) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$1,002
KEAP1 Mouse anti-Human Monoclonal (OTI1A1) Antibody
Human
Flo, WB
Unconjugated
100 µl/$434
KEAP1 Rabbit anti-Human Polyclonal (APC) Antibody
Mouse, Rat, Human
ICC, WB
APC Conjugated
100 µl/$1,089
KEAP1 Mouse anti-Human Monoclonal (Amino Acid: 380-624) (1F10B6) Antibody
Mouse, Human
Flo, ICC, IF, WB
Unconjugated
100 µl/$492
KEAP1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$351
KEAP1 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-P
Unconjugated
50 µl/$317; 100 µl/$375; 200 µl/$473
KEAP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
KEAP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
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