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Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.
Gene Name: | lysine (K)-specific demethylase 6A |
Synonyms: | KDM6A, BA386N14.2, Lysine-specific demethylase 6A, UTX, Histone demethylase UTX, KABUK2 |
Target Sequences: | NM_021140 NP_066963.2 O15550 |
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