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Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.
Gene Name: | lysine (K)-specific demethylase 4A |
Synonyms: | KDM4A, JMJD2A, Jumonji domain containing 2A, JMJD2, Jumonji domain containing 2, KIAA0677, JHDM3A, Lysine-specific demethylase 4A |
Target Sequences: | NM_014663 NP_055478.2 O75164 |
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