KDM1A / LSD1

lysine (K)-specific demethylase 1A

Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7.

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Proteins (6)

Type

Over-Expression Lysate (4)

Recombinant (2)

Target

KDM1A / LSD1 (6)

Publications

No (6)

Tag

GST (1)

Myc-DDK (Flag) (5)

Species

Human (4)

Source

293T Cells (2)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (1)

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KDM1A / LSD1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G130288

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

95.6 kDa

Price:

100 µg/$710

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Human KDM1A / LSD1 Protein (Recombinant GST) (Full Length) - LS-G32707

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

121.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human KDM1A / LSD1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72544

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

95.6 kDa

Price:

20 µg/$1,107

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KDM1A / LSD1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101284

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

92.7 kDa

Price:

100 µg/$494

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Human KDM1A / LSD1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92842

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

95.6 kDa

Price:

20 µg/$215

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Human KDM1A / LSD1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92843

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

92.7 kDa

Price:

20 µg/$150

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