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KCNN2

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants.

Gene Name:	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Family/Subfamily:	Ion Channel , Potassium channel - calcium-activated
Synonyms:	KCNN2, HSK2, KCa2.2, Sk2, SKCA2, SKCa 2
Target Sequences:	NM_021614 NP_067627.2 Q9H2S1

Publications (2)

Electrogenic transport and K(+) ion channel expression by the human endolymphatic sac epithelium. Kim SH, Kim BG, Kim JY, Roh KJ, Suh MJ, Jung J, Moon IS, Moon SK, Choi JY. Scientific reports. 2015 5:18110. (IHC; Human) [Full Text Article] [PubMed:26655723] [PMC:PMC4677336] Related Antibodies: LS-A9578.

Heterogeneous upregulation of apamin-sensitive potassium currents in failing human ventricles. Chang PC, Turker I, Lopshire JC, Masroor S, Nguyen BL, Tao W, Rubart M, Chen PS, Chen Z, Ai T. Journal of the American Heart Association. 2013 2:e004713. (WB; Human) [Full Text Article] [PubMed:23525437] Related Antibodies: LS-B4408.

Human KCNN2 (Sandwich ELISA) ELISA Kit - LS-F6844

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$902

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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