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KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.
| Gene Name: | potassium large conductance calcium-activated channel, subfamily M, beta member 4 |
| Family/Subfamily: | Ion Channel , Potassium channel - calcium-activated |
| Synonyms: | KCNMB4, BK beta 4, BK channel subunit beta-4, BKbeta4, Hbeta4, K(VCA)beta-4, Slowpoke beta 4, Maxi K channel subunit beta-4, Maxi K beta 4, Slo-beta-4 |
| Target Sequences: | NM_014505 NP_055320.4 Q86W47 |
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