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KCNK2 / TREK-1
potassium channel, subfamily K, member 2
TREK1 is a 2 pore-domain 4 transmembrane domain background potassium channel expressed throughout the central nervous system with lower levels in peripheral tissues. It is opened by polyunsaturated fatty acids, lysophospholipids, and volatile anesthetics. It is inhibited by neurotransmitters that increase intracellular cAMP or activate the Gq signaling pathway. Studies in mice suggest that TREK1 plays a role in neuroprotection against epilepsy and ischemia afforded by polyunsaturated fatty acids and lysophospholipids and in anesthesia induced by volatile anesthetics.
| Gene Name: | potassium channel, subfamily K, member 2 |
| Family/Subfamily: | Ion Channel , Potassium channel - two pore |
| Synonyms: | KCNK2, HTREK-1c, K2p2.1, TREK-1 K(+) channel subunit, TREK1, Two-pore potassium channel 1, HTREK-1e, K2P2.1 potassium channel, TPKC1, TREK-1 |
| Target Sequences: | NM_001017424 NP_055032.1 O95069 |
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