KCNJ11 / Kir6.2

potassium inwardly-rectifying channel, subfamily J, member 11

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

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Products

Proteins (2)

Type

Recombinant (2)

Target

KCNJ11 / Kir6.2 (2)

Publications

No (2)

Tag

GST (1)

GST, N-terminus (1)

Species

Human (2)

Source

Wheat Germ Extract (2)

Purification

Purified (1)

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Human KCNJ11 / Kir6.2 Protein (Recombinant GST) (Full Length) - LS-G29114

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

69.9 kDa

Price:

2 µg/$439

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Human KCNJ11 / Kir6.2 Protein (Recombinant GST, N-terminus) (aa301-390) - LS-G59056

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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