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Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
Gene Name: | potassium voltage-gated channel, Isk-related family, member 1 |
Family/Subfamily: | Ion Channel , Potassium channel - KCNE |
Synonyms: | KCNE1, JLNS, LQT5, MinK, JLNS2, LQT2/5, Minimal potassium channel, ISK |
Target Sequences: | NM_000219 NP_000210.2 P15382 |
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