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KATII / AADAT

aminoadipate aminotransferase

Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).

Gene Name:	aminoadipate aminotransferase
Synonyms:	AADAT, 2-aminoadipate transaminase, KAT2, KAT/AadAT, KATII, Kynurenine aminotransferase II, Aminoadipate aminotransferase
Target Sequences:	NM_016228 NP_057312.1 Q8N5Z0

Publications (1)

Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans. Schlittler M, Goiny M, Agudelo LZ, Venckunas T, Brazaitis M, Skurvydas A, Kamandulis S, Ruas JL, Erhardt S, Westerblad H, Andersson DC. American journal of physiology. Cell physiology. 2016 May;310:C836-C840. [Full Text Article] [PubMed:27030575] Related Antibodies: LS-C309277.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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